Weed resistance is a critical issue in crop production. Among the known herbicides, 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibitors are crucial for addressing weed resistance. HPPD inhibitors constitute a pivotal aspect of contemporary crop protection strategies. The advantages of these herbicides are their broad weed spectrum, flexible application, and excellent compatibility with other herbicides. They also exhibit satisfactory crop selectivity and low toxicity and are environmentally friendly. An increasing number of new HPPD inhibitors have been designed by combining computer-aided drug design with conventional design approaches. Herein, the molecular design and structural features of innovative HPPD inhibitors are reviewed to guide the development of new HPPD inhibitors possessing an enhanced biological efficacy.

中文翻译：

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4-羟基苯丙酮酸双加氧酶抑制剂：从分子设计到合成


杂草抗性是作物生产中的一个关键问题。在已知的除草剂中，4-羟基苯基丙酮酸双加氧酶（HPPD）抑制剂对于解决杂草抗性至关重要。 HPPD 抑制剂是当代作物保护策略的一个关键方面。这些除草剂的优点是杂草谱广、施用灵活、与其他除草剂具有良好的配伍性。它们还表现出令人满意的作物选择性和低毒性并且对环境友好。通过将计算机辅助药物设计与传统设计方法相结合，设计出了越来越多的新型 HPPD 抑制剂。本文综述了创新HPPD抑制剂的分子设计和结构特征，以指导开发具有增强生物功效的新型HPPD抑制剂。