Hypervalent iodine reagents are versatile and readily accessible reagents that have been extensively applied in contemporary synthesis in modern organic chemistry. Among them, iodonitrene (ArI=NR), is a powerful reactive species, widely used for a single‐nitrogen‐atom insertion reaction, and skeletal editing to construct N‐heterocycles. Skeletal editing with reactive iodonitrene components has recently emerged as an exciting approach in modern chemical transformation. These reagents have been extensively used to produce biologically relevant heterocycles and functionalized molecular architectures. Recently, the insertion of a nitrogen‐atom into hydrocarbons to generate N‐heterocyclic compounds using hypervalent iodine reagents has been a significant focus in the field of molecular editing reactions. In this review, we discuss the rapidly emerging field of nitrene insertion, including skeletal editing and nitrogen insertion, using hypervalent iodine reagents to access nitrogen‐containing heterocycles, and the current mechanistic understanding of these processes.

中文翻译：

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通过高价碘介导的氮插入进行骨骼编辑


高价碘试剂是通用且易于获得的试剂，已广泛应用于现代有机化学的当代合成中。其中，碘氮烯（ArI=NR）是一种强大的活性物质，广泛用于单氮原子插入反应和骨架编辑以构建N杂环。使用活性碘氮化合物进行骨架编辑最近已成为现代化学转化中令人兴奋的方法。这些试剂已广泛用于生产生物学相关的杂环和功能化分子结构。最近，利用高价碘试剂将氮原子插入烃中生成N-杂环化合物已成为分子编辑反应领域的一个重要焦点。在这篇综述中，我们讨论了快速新兴的氮宾插入领域，包括骨架编辑和氮插入，使用高价碘试剂来获取含氮杂环，以及目前对这些过程的机械理解。