A continuous synthesis of two plant activators, tiadinil and methiadinil, was developed by using reaction chips. After exploring the synthetic approach in batch at the first stage, the key intermediate 4-methyl-1,2,3-thiadiazole-5-carboxylic acid was prepared in 70% yield by using a hybrid device equipped with two reaction chips. Tiadinil and methiadinil were then obtained in 88 and 81% yields, respectively, through a quick condensation reaction (81 s) in a reaction chip. This study showcases the potential of continuous flow chemistry in the field of agricultural and fine chemicals.

中文翻译：

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在集成连续流系统下按需生产两种商业植物活化剂：噻地尼和甲噻地尼


利用反应芯片开发了两种植物激活剂噻地尼和甲噻地尼的连续合成。经过第一阶段批量合成方法的探索，利用配备两个反应芯片的混合装置，以70%的收率制备了关键中间体4-甲基-1,2,3-噻二唑-5-甲酸。然后通过反应芯片中的快速缩合反应（81秒）分别以88%和81%的产率获得了噻菌胺和甲噻菌胺。这项研究展示了连续流动化学在农业和精细化学品领域的潜力。