Photocatalytic Synthesis of γ,γ-Difluoroallylic Ketones and δ,δ-Difluoroallylic Ketones via a Desulfurative/Defluorinative Alkylation Process,Organic Letters

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Photocatalytic Synthesis of γ,γ-Difluoroallylic Ketones and δ,δ-Difluoroallylic Ketones via a Desulfurative/Defluorinative Alkylation Process
Organic Letters ( IF 4.9 ) Pub Date : 2024-07-23 , DOI: 10.1021/acs.orglett.4c02232
Yunqi Liu _{1,

2} , Xiyan Zhou _{1,

2} , Ruining Li _{1,

2} , Zhankui Sun _{1,

2,

3}

Affiliation

The gem-difluoroalkene moiety is frequently found in medicinal chemistry. From α-keton sulfides and thioic acids, we were able to develop a universal approach for the synthesis of γ,γ-difluoroallylic ketones and δ,δ-difluoroallylic ketones via a desulfurative/defluorinative alkylation process. We expect that this mild and efficient method will be complementary to other known strategies.

中文翻译：

通过脱硫/脱氟烷基化过程光催化合成γ,γ-二氟烯丙基酮和δ,δ-二氟烯丙基酮

偕二氟烯烃部分常见于药物化学中。从 α-酮硫化物和硫代酸，我们能够开发出一种通过脱硫/脱氟烷基化过程合成 γ,γ-二氟烯丙酮和 δ,δ-二氟烯丙酮的通用方法。我们期望这种温和而有效的方法将与其他已知策略形成补充。

更新日期：2024-07-23

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