Oxidative Difunctionalization of N-Aryl Bicyclobutyl Amides with Aldehydes: Divergent Synthesis of Acylated and Alkylated 3-Spirocyclobutyl Oxindoles,Organic Letters

当前位置： X-MOL 学术 › Org. Lett. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Oxidative Difunctionalization of N-Aryl Bicyclobutyl Amides with Aldehydes: Divergent Synthesis of Acylated and Alkylated 3-Spirocyclobutyl Oxindoles
Organic Letters ( IF 4.9 ) Pub Date : 2024-07-23 , DOI: 10.1021/acs.orglett.4c02325
Peng-Fei Xia ₁ , Jiao Zhou ₁ , Jing Yuan ₁ , Rui Zeng ₁ , Yu Liu ₁ , Ke-Wen Tang ₁ , Jian-Hong Fan ₁

Affiliation

An efficient and operationally simple oxidative radical difunctionalization of N-aryl bicyclobutyl (BCB) amides with aldehydes is described. It was found that acylated 3-spirocyclobutyl oxindoles were generated from the coupling of BCB-amides and aromatic aldehydes, while reactions gave exclusively decarbonylative alkylarylation products using alkyl aldehydes as radical precursors.

中文翻译：

N-芳基双环丁基酰胺与醛的氧化双官能化：酰化和烷基化 3-螺环丁基羟吲哚的不同合成

描述了N-芳基双环丁基 (BCB) 酰胺与醛的有效且操作简单的氧化自由基双官能化。研究发现，酰化3-螺环丁基羟吲哚是由BCB-酰胺和芳香醛偶联生成的，而使用烷基醛作为自由基前体的反应仅产生脱羰烷基芳基化产物。

更新日期：2024-07-23

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南