Herein, we describe a novel photoinduced iron-catalyzed strategy for multicomponent C–H alkylation of in situ generated imines. By utilizing the alkyl radicals generated through iron-mediated photocatalytic C–H activation, the imines formed in situ are further subjected to addition reactions, resulting in the synthesis of various secondary and tertiary amine products. This method is simple to operate and does not require additional oxidants. It is applicable to inert alkane substrates such as cyclic alkanes, cyclic ethers, toluene, and ketones. The reaction is also compatible with various aromatic amines, alkyl amines, halogenated aromatic amines, as well as aromatic aldehydes, alkyl aldehydes, and cinnamaldehyde, among other different types of aldehydes.

中文翻译：

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通过光诱导配体到金属电荷转移原位生成亚胺的铁催化多组分 C–H 烷基化


在此，我们描述了一种新的光诱导铁催化策略，用于原位生成的亚胺的多组分C-H烷基化。利用铁介导的光催化C-H活化产生的烷基自由基，原位形成的亚胺进一步发生加成反应，从而合成各种仲胺和叔胺产物。该方法操作简单，不需要额外的氧化剂。适用于环烷烃、环醚、甲苯、酮等惰性烷烃底物。该反应还与各种芳香胺、烷基胺、卤代芳香胺以及芳香醛、烷基醛和肉桂醛以及其他不同类型的醛相容。