Prephenate decarboxylase: An unexplored branchpoint to unusual natural products,Cell Chemical Biology

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Prephenate decarboxylase: An unexplored branchpoint to unusual natural products
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-07-25 , DOI: 10.1016/j.chembiol.2024.06.015
Mostafa Hagar ₁ , Raymond J Andersen ₂ , Katherine S Ryan ₁

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Prephenate decarboxylases are a small family of enzymes which initiate a specialized divergence from the shikimate pathway, where prephenate (2) is decarboxylated without aromatization. In addition to effecting a challenging chemical transformation, prephenate decarboxylases have been implicated in the production of rare specialized metabolites, sometimes directly constructing bioactive warheads. Many of the biosynthetic steps to natural products derived from prephenate decarboxylases remain elusive. Here, we review prephenate decarboxylase research thus far and highlight natural products that may be derived from biosynthetic pathways involving prephenate decarboxylases. We also highlight commonly encountered challenges in the structure elucidation of these natural products. Prephenate decarboxylases are a gateway into understudied biosynthetic pathways which present a high potential for the discovery of novel and bioactive natural products, as well as new biosynthetic enzymes.

中文翻译：

预苯酯脱羧酶：不寻常天然产物的一个未探索的分支点

预苯酯脱羧酶是一个小家族的酶，它引发与莽草酸途径的专门分歧，其中预苯酯 (2) 脱羧而不芳构化。除了实现具有挑战性的化学转化之外，预苯酸脱羧酶还参与稀有专门代谢物的生产，有时直接构建生物活性弹头。来自预苯酯脱羧酶的天然产物的许多生物合成步骤仍然难以捉摸。在这里，我们回顾了迄今为止的预苯酸脱羧酶研究，并重点介绍了可能源自涉及预苯酸脱羧酶的生物合成途径的天然产物。我们还强调了这些天然产物结构解析中常见的挑战。预苯酸脱羧酶是进入未被充分研究的生物合成途径的门户，该途径为发现新颖的生物活性天然产物以及新的生物合成酶提供了巨大的潜力。

更新日期：2024-07-25

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