Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells “hyperactivated” by specific adjuvants elicit T_H1-skewed CD4⁺ T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.

中文翻译：

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通过过度激活树突状细胞“增强”老年小鼠的肿瘤免疫力

免疫衰老对老年人的肿瘤免疫治疗提出了重大挑战。在本期《细胞》杂志中，Zhivaki 等人。阐明特定佐剂“过度激活”的树突状细胞以取决于 NLRP3 炎性体的方式引发 T _H 1 偏向 CD4 ⁺ T 细胞反应，从而消除老年小鼠的肿瘤。