Advances in α-Hydroxylation of β-Dicarbonyl Compounds,Advanced Synthesis & Catalysis

当前位置： X-MOL 学术 › Adv. Synth. Catal. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Advances in α-Hydroxylation of β-Dicarbonyl Compounds
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-07-23 , DOI: 10.1002/adsc.202400627
Shuai Peng ₁ , Fangyao Su ₁ , Shuting Yin ₁ , baoguo sun ₂ , Hongyu Tian ₃ , Sen Liang ₄

Affiliation

The α-hydroxy-β-dicarbonyl motif is essential in many biologically active compounds, sparking significant interest in their synthesis. This review comprehensively examines the advancements in the α-hydroxylation of β-dicarbonyl compounds, systematically categorizing the methods based on the types of oxidants employed and highlighting advances in asymmetric α-hydroxylation. It evaluates the substrate scope, advantages, and disadvantages of each approach, summarizing the possible intermediates involved and the types of reaction mechanisms.

中文翻译：