Natural Product-Inspired Dopamine Receptor Ligands,Journal of Medicinal Chemistry

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Natural Product-Inspired Dopamine Receptor Ligands
Journal of Medicinal Chemistry ( IF 6.8 ) Pub Date : 2024-07-22 , DOI: 10.1021/acs.jmedchem.4c00537
Michael Dorogan ₁ , Hari K Namballa ₁ , Wayne W Harding _{1,

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Affiliation

Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as lead compounds in drug discovery. Given the involvement of dopamine receptors in various physiological and behavioral functions, they are linked to numerous diseases and disorders such as Parkinson’s disease, schizophrenia, and substance use disorders. Consequently, ligands targeting dopamine receptors hold considerable therapeutic and investigative promise. As this perspective will highlight, dopamine receptor targeting natural products play a pivotal role as scaffolds with unique and beneficial pharmacological properties, allowing for natural product-inspired drug design and lead optimization. As such, dopamine receptor targeting natural products still have untapped potential to aid in the treatment of disorders and diseases related to central nervous system (CNS) and peripheral nervous system (PNS) dysfunction.

中文翻译：

天然产物启发的多巴胺受体配体

由于天然产物作为生物学相关药物靶标的配体的进化偏差，为药物发现中作为先导化合物提供了独特的机会。鉴于多巴胺受体参与各种生理和行为功能，它们与许多疾病和病症有关，例如帕金森病、精神分裂症和物质使用障碍。因此，靶向多巴胺受体的配体具有相当大的治疗和研究前景。正如这一观点所强调的，靶向天然产物的多巴胺受体作为具有独特和有益的药理学特性的支架发挥着关键作用，允许天然产物启发的药物设计和先导化合物优化。因此，针对天然产物的多巴胺受体在帮助治疗与中枢神经系统（CNS）和周围神经系统（PNS）功能障碍相关的紊乱和疾病方面仍然具有未开发的潜力。

更新日期：2024-07-22

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