Synthesis of 1-Azabicyclo[2.1.1]hexanes via Formal Single Electron Reduction of Azabicyclo[1.1.0]butanes under Photochemical Conditions,Angewandte Chemie International Edition

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Synthesis of 1-Azabicyclo[2.1.1]hexanes via Formal Single Electron Reduction of Azabicyclo[1.1.0]butanes under Photochemical Conditions
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-07-22 , DOI: 10.1002/anie.202410207
Margherita Zanini ₁ , Adam Noble ₁ , Varinder Kumar Aggarwal ₂

Affiliation

A general synthesis of 1-azabicyclo[2.1.1]hexanes (1-aza-BCH) starting from azabicyclo[1.1.0]butanes (ABB) and styrenes under photochemical conditions is reported. The reaction follows a polar-radical-polar relay strategy in which the key step is a photocatalytic atom-transfer-radical-addition (ATRA) reaction.

中文翻译：

光化学条件下氮杂双环[1.1.0]丁烷的形式单电子还原合成1-氮杂双环[2.1.1]己烷

报道了在光化学条件下以氮杂双环[1.1.0]丁烷(ABB)和苯乙烯为起始原料1-氮杂双环[2.1.1]己烷(1-氮杂-BCH)的一般合成。该反应遵循极性-自由基-极性接力策略，其中关键步骤是光催化原子转移-自由基加成（ATRA）反应。

更新日期：2024-07-22

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