In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway,Advanced Materials

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In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway
Advanced Materials ( IF 27.4 ) Pub Date : 2024-07-23 , DOI: 10.1002/adma.202406434
Qingqiao Xie _{1,

2,

3} , Chenchen Yan ₄ , Guohui Liu ₅ , Liming Bian _{1,

2,

3} , Kunyu Zhang _{1,

2,

3}

Affiliation

Chronic nonhealing skin wounds, characterized by reduced tissue contractility and inhibited wound cell survival under hyperglycemia and hypoxia, present a significant challenge in diabetic care. Here, an advanced self-contraction bioactive core-shell microgel assembly with robust tissue-adhesion (SMART-EXO) is introduced to expedite diabetic wound healing. The SMART-EXO dressing exhibits strong, reversible adhesion to damaged tissue due to abundant hydrogen and dynamic coordination bonds. Additionally, the core-shell microgel components and dynamic coordination bonds provide moderate rigidity, customizable self-contraction, and an interlinked porous architecture. The triggered in situ self-contraction of the SMART-EXO dressing enables active, tunable wound contraction, activating mechanotransduction in the skin and promoting the optimal fibroblast-to-myofibroblast conversion, collagen synthesis, and angiogenesis. Concurrently, the triggered contraction of SMART-EXO facilitates efficient loading and on-demand release of bioactive exosomes, contributing to re-epithelialization and wound microenvironment regulation in diabetic mice. RNA-seq results reveal the activation of critical signaling pathways associated with mechanosensing and exosome regulation, highlighting the combined biomechanical and biochemical mechanisms. These findings underscore SMART-EXO as a versatile, adaptable solution to the complex challenges of diabetic wound care.

中文翻译：

原位触发自收缩生物活性微凝胶组装通过激活力传导和生化途径加速糖尿病皮肤伤口愈合

慢性不愈合皮肤伤口的特点是在高血糖和缺氧情况下组织收缩力降低并抑制伤口细胞存活，这对糖尿病护理提出了重大挑战。在这里，引入了一种具有强大组织粘附力的先进自收缩生物活性核壳微凝胶组件（SMART-EXO），以加速糖尿病伤口愈合。由于丰富的氢和动态配位键，SMART-EXO 敷料对受损组织表现出强大的可逆粘附力。此外，核壳微凝胶成分和动态配位键提供了适度的刚性、可定制的自收缩和互连的多孔结构。 SMART-EXO 敷料触发的原位自收缩可实现主动、可调节的伤口收缩，激活皮肤中的机械传导，并促进最佳的成纤维细胞到肌成纤维细胞的转化、胶原蛋白合成和血管生成。同时，SMART-EXO 的触发收缩有助于生物活性外泌体的有效加载和按需释放，有助于糖尿病小鼠的上皮再形成和伤口微环境调节。 RNA-seq结果揭示了与机械传感和外泌体调节相关的关键信号通路的激活，突出了生物力学和生化的结合机制。这些发现强调 SMART-EXO 作为一种多功能、适应性强的解决方案，可以应对糖尿病伤口护理的复杂挑战。

更新日期：2024-07-23

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