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Visible Light-Responsive Polyphenolic Bio-Glues for Oral Mucosal Wound Healing
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-07-23 , DOI: 10.1002/adfm.202408462 Hengjie Zhang 1 , Jianhua Zhang 1 , Tianyou Wang 1 , Haotian Li 1 , Rong Zhang 1 , Xianchun Chen 1 , Zhipeng Gu 1 , Yiwen Li 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-07-23 , DOI: 10.1002/adfm.202408462 Hengjie Zhang 1 , Jianhua Zhang 1 , Tianyou Wang 1 , Haotian Li 1 , Rong Zhang 1 , Xianchun Chen 1 , Zhipeng Gu 1 , Yiwen Li 1
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Although bio-adhesives have achieved many progresses, creating robust bio-glues that could withstand the complex physiological microenvironment remains a significant challenge such as limited bioadhesion strength and stability, as well as slow adhesion speed caused by pH, enzymes, salt, and bacteria. Herein, a series of strong bio-glues are successfully fabricated using a polyphenol–acrylamide–ruthenium crosslinking (PARC) reaction under visible light irradiation, involving acrylamides radical polymerization, polyphenols (extracts) coupling reaction, and ruthenium-mediated photochemistry. The resulting bio-glues underwent rapid sol–gel transition and exhibited adhesive properties within a short of time (≈5 s), which could quickly bond to various bio-tissues. Moreover, these bioadhesives demonstrate high adhesion strength and stability with mucosal tissue in the oral environment, effectively promoting rat and pig oral mucosal wound healing. It is anticipated that this class of visible light-responsive polyphenolic bio-glues could serve as a robust tool for addressing oral mucosal defects in the clinic, offering a promising alternative to traditional treatments for oral mucosal disorders.
中文翻译：
用于口腔粘膜伤口愈合的可见光响应多酚生物胶
尽管生物胶粘剂已经取得了许多进展，但创造能够承受复杂生理微环境的坚固生物胶仍然是一个重大挑战，例如生物粘附强度和稳定性有限，以及 pH 值、酶、盐和细菌导致的粘附速度缓慢。在此，在可见光照射下使用多酚-丙烯酰胺-钌交联 （PARC） 反应成功制备了一系列强生物胶，涉及丙烯酰胺自由基聚合、多酚（提取物）偶联反应和钌介导的光化学。所得生物胶经历了快速的溶胶-凝胶转变，并在短时间内 （≈5 s） 表现出粘合性能，可以快速粘合到各种生物组织上。此外，这些生物粘合剂在口腔环境中表现出与粘膜组织的高粘附强度和稳定性，有效促进大鼠和猪口腔粘膜伤口愈合。预计这类可见光响应性多酚生物胶可以成为临床上解决口腔粘膜缺损的强大工具，为口腔粘膜疾病的传统治疗方法提供有前途的替代方案。
更新日期：2024-07-23
中文翻译：
用于口腔粘膜伤口愈合的可见光响应多酚生物胶
尽管生物胶粘剂已经取得了许多进展，但创造能够承受复杂生理微环境的坚固生物胶仍然是一个重大挑战，例如生物粘附强度和稳定性有限，以及 pH 值、酶、盐和细菌导致的粘附速度缓慢。在此，在可见光照射下使用多酚-丙烯酰胺-钌交联 （PARC） 反应成功制备了一系列强生物胶，涉及丙烯酰胺自由基聚合、多酚（提取物）偶联反应和钌介导的光化学。所得生物胶经历了快速的溶胶-凝胶转变，并在短时间内 （≈5 s） 表现出粘合性能，可以快速粘合到各种生物组织上。此外，这些生物粘合剂在口腔环境中表现出与粘膜组织的高粘附强度和稳定性，有效促进大鼠和猪口腔粘膜伤口愈合。预计这类可见光响应性多酚生物胶可以成为临床上解决口腔粘膜缺损的强大工具，为口腔粘膜疾病的传统治疗方法提供有前途的替代方案。
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