当前位置：
X-MOL 学术
›
Chem. Soc. Rev.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Exploring pathological link between antimicrobial and amyloid peptides
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-07-23 , DOI: 10.1039/d3cs00878a Yijing Tang 1 , Yanxian Zhang 2 , Dong Zhang 3 , Yonglan Liu 4 , Ruth Nussinov 5, 6 , Jie Zheng 1
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-07-23 , DOI: 10.1039/d3cs00878a Yijing Tang 1 , Yanxian Zhang 2 , Dong Zhang 3 , Yonglan Liu 4 , Ruth Nussinov 5, 6 , Jie Zheng 1
Affiliation
|
Amyloid peptides (AMYs) and antimicrobial peptides (AMPs) are considered as the two distinct families of peptides, characterized by their unique sequences, structures, biological functions, and specific pathological targets. However, accumulating evidence has revealed intriguing pathological connections between these peptide families in the context of microbial infection and neurodegenerative diseases. Some AMYs and AMPs share certain structural and functional characteristics, including the ability to self-assemble, the presence of β-sheet-rich structures, and membrane-disrupting mechanisms. These shared features enable AMYs to possess antimicrobial activity and AMPs to acquire amyloidogenic properties. Despite limited studies on AMYs–AMPs systems, the cross-seeding phenomenon between AMYs and AMPs has emerged as a crucial factor in the bidirectional communication between the pathogenesis of neurodegenerative diseases and host defense against microbial infections. In this review, we examine recent developments in the potential interplay between AMYs and AMPs, as well as their pathological implications for both infectious and neurodegenerative diseases. By discussing the current progress and challenges in this emerging field, this account aims to inspire further research and investments to enhance our understanding of the intricate molecular crosstalk between AMYs and AMPs. This knowledge holds great promise for the development of innovative therapies to combat both microbial infections and neurodegenerative disorders.
中文翻译：
探索抗菌肽和淀粉样肽之间的病理联系
淀粉样肽（AMY）和抗菌肽（AMP）被认为是两个不同的肽家族，具有独特的序列、结构、生物学功能和特定的病理靶点。然而，越来越多的证据表明，在微生物感染和神经退行性疾病的背景下，这些肽家族之间存在着有趣的病理联系。一些 AMY 和 AMP 具有某些相同的结构和功能特征，包括自组装能力、富含 β-折叠结构的存在以及膜破坏机制。这些共同的特征使 AMY 具有抗菌活性，而 AMP 则获得淀粉样蛋白生成特性。尽管对 AMYs-AMPs 系统的研究有限，但 AMYs 和 AMPs 之间的交叉播种现象已成为神经退行性疾病发病机制和宿主对抗微生物感染的防御之间双向通讯的关键因素。在这篇综述中，我们研究了 AMY 和 AMP 之间潜在相互作用的最新进展，以及它们对传染病和神经退行性疾病的病理学影响。通过讨论这一新兴领域当前的进展和挑战，本账户旨在激发进一步的研究和投资，以增强我们对 AMY 和 AMP 之间复杂的分子串扰的理解。这些知识为开发对抗微生物感染和神经退行性疾病的创新疗法带来了巨大希望。
更新日期：2024-07-23
中文翻译：
探索抗菌肽和淀粉样肽之间的病理联系
淀粉样肽（AMY）和抗菌肽（AMP）被认为是两个不同的肽家族，具有独特的序列、结构、生物学功能和特定的病理靶点。然而，越来越多的证据表明，在微生物感染和神经退行性疾病的背景下，这些肽家族之间存在着有趣的病理联系。一些 AMY 和 AMP 具有某些相同的结构和功能特征，包括自组装能力、富含 β-折叠结构的存在以及膜破坏机制。这些共同的特征使 AMY 具有抗菌活性，而 AMP 则获得淀粉样蛋白生成特性。尽管对 AMYs-AMPs 系统的研究有限，但 AMYs 和 AMPs 之间的交叉播种现象已成为神经退行性疾病发病机制和宿主对抗微生物感染的防御之间双向通讯的关键因素。在这篇综述中，我们研究了 AMY 和 AMP 之间潜在相互作用的最新进展，以及它们对传染病和神经退行性疾病的病理学影响。通过讨论这一新兴领域当前的进展和挑战，本账户旨在激发进一步的研究和投资，以增强我们对 AMY 和 AMP 之间复杂的分子串扰的理解。这些知识为开发对抗微生物感染和神经退行性疾病的创新疗法带来了巨大希望。
京公网安备 11010802027423号