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Phytofabricated ZnO-NPs mediated by Hibiscus tiliaceus leaf extract and its potential as a diosgenin delivery vehicle
RSC Advances ( IF 3.9 ) Pub Date : 2024-07-23 , DOI: 10.1039/d4ra03249g Oktavina Kartika Putri 1, 2 , Lina Oktavia Rahayu 2 , Yuly Kusumawati 1 , Arif Fadlan 1 , Riki Subagyo 1 , Mardi Santoso 1
RSC Advances ( IF 3.9 ) Pub Date : 2024-07-23 , DOI: 10.1039/d4ra03249g Oktavina Kartika Putri 1, 2 , Lina Oktavia Rahayu 2 , Yuly Kusumawati 1 , Arif Fadlan 1 , Riki Subagyo 1 , Mardi Santoso 1
Affiliation
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Zinc oxide nanoparticles (ZnO-NPs) have provided promising potential in the biomedical field, including the ability to overcome various health problems. Diosgenin is used to treat multiple health disorders but has very low solubility in water. Using ZnO-NPs as a diosgenin delivery vehicle was expected to increase the solubility of diosgenin, which would affect its bioavailability. This study demonstrates phytofabrication and characterization of ZnO-NPs, loading of diosgenin onto the ZnO-NPs, characterization of the product (ZnO-NPs/diosgenin), and evaluations of diosgenin release. Phytofabrication of the ZnO-NPs was carried out with zinc precursors and Hibiscus tiliaceus leaf extract (HLE) obtained with various extraction solvents. To explore the potential of using the ZnO-NPs as a diosgenin delivery vehicle, diosgenin release from the ZnO-NPs/diosgenin was studied. Based on the X-ray fluorescence (XRF) and X-ray diffraction (XRD) results, ZnO-NPs with high purity have been successfully fabricated. Nano-sized particles were detected using scanning electron microscopy (SEM) and confirmed by transmission electron microscopy (TEM), revealing the smallest particle size of 45.924 ± 27.910 nm obtained from the methanol extract with the zinc acetate precursor. The ZnO-NPs had hexagonal wurtzite and rod-like structures. Diosgenin was successfully added to the ZnO-NPs with loadings of 79.972% for ZnO-HLMEA-D500 (ZnO-NPs/diosgenin produced by doping with a 500 μg mL−1 of diosgenin solution) and 39.775% for ZnO-HLMEA-D1000 (ZnO-NPs/diosgenin produced by doping with a 1000 μg mL−1 of diosgenin solution). The solubilities of diosgenin from ZnO-HLMEA-D500 and ZnO-HLMEA-D1000 were higher than that of free diosgenin, confirming that ZnO-NPs have potential as delivery vehicles for diosgenin and conceivably other water-insoluble drugs.
中文翻译：
黄槿叶提取物介导的植物化 ZnO-NP 及其作为薯蓣皂苷元递送载体的潜力
氧化锌纳米颗粒（ZnO-NP）在生物医学领域具有广阔的前景，包括克服各种健康问题的能力。薯蓣皂苷元用于治疗多种健康疾病，但在水中的溶解度非常低。使用 ZnO-NPs 作为薯蓣皂苷元递送载体预计会增加薯蓣皂苷元的溶解度，从而影响其生物利用度。本研究展示了 ZnO-NPs 的植物制造和表征、将薯蓣皂苷元负载到 ZnO-NPs 上、产品（ZnO-NPs/薯蓣皂苷元）的表征以及薯蓣皂苷元释放的评估。使用锌前体和用各种提取溶剂获得的黄槿叶提取物 (HLE) 进行 ZnO-NP 的植物制造。为了探索使用 ZnO-NPs 作为薯蓣皂苷元递送载体的潜力，研究了 ZnO-NPs/薯蓣皂苷元中薯蓣皂苷元的释放。根据X射线荧光（XRF）和X射线衍射（XRD）结果，成功制备了高纯度的ZnO-NPs。使用扫描电子显微镜 (SEM) 检测纳米尺寸颗粒，并通过透射电子显微镜 (TEM) 确认，显示从含有乙酸锌前体的甲醇提取物中获得的最小颗粒尺寸为 45.924 ± 27.910 nm。 ZnO-NPs 具有六方纤锌矿和棒状结构。薯蓣皂苷元成功添加到ZnO-NPs中，ZnO-HLMEA-D 500 （通过掺杂500 μg mL -1薯蓣皂苷元溶液产生的ZnO-NPs/薯蓣皂苷元）载量为79.972％，ZnO-HLMEA-D载量为39.775％ 1000 （通过掺杂1000 μg mL -1的薯蓣皂苷元溶液产生的ZnO-NPs/薯蓣皂苷元）。 ZnO-HLMEA-D 500和 ZnO-HLMEA-D 1000中的薯蓣皂苷元的溶解度高于游离薯蓣皂苷元的溶解度，证实 ZnO-NPs 具有作为薯蓣皂苷元和可能的其他水不溶性药物的递送载体的潜力。
更新日期：2024-07-23
中文翻译：
黄槿叶提取物介导的植物化 ZnO-NP 及其作为薯蓣皂苷元递送载体的潜力
氧化锌纳米颗粒（ZnO-NP）在生物医学领域具有广阔的前景，包括克服各种健康问题的能力。薯蓣皂苷元用于治疗多种健康疾病，但在水中的溶解度非常低。使用 ZnO-NPs 作为薯蓣皂苷元递送载体预计会增加薯蓣皂苷元的溶解度，从而影响其生物利用度。本研究展示了 ZnO-NPs 的植物制造和表征、将薯蓣皂苷元负载到 ZnO-NPs 上、产品（ZnO-NPs/薯蓣皂苷元）的表征以及薯蓣皂苷元释放的评估。使用锌前体和用各种提取溶剂获得的黄槿叶提取物 (HLE) 进行 ZnO-NP 的植物制造。为了探索使用 ZnO-NPs 作为薯蓣皂苷元递送载体的潜力，研究了 ZnO-NPs/薯蓣皂苷元中薯蓣皂苷元的释放。根据X射线荧光（XRF）和X射线衍射（XRD）结果，成功制备了高纯度的ZnO-NPs。使用扫描电子显微镜 (SEM) 检测纳米尺寸颗粒，并通过透射电子显微镜 (TEM) 确认，显示从含有乙酸锌前体的甲醇提取物中获得的最小颗粒尺寸为 45.924 ± 27.910 nm。 ZnO-NPs 具有六方纤锌矿和棒状结构。薯蓣皂苷元成功添加到ZnO-NPs中，ZnO-HLMEA-D 500 （通过掺杂500 μg mL -1薯蓣皂苷元溶液产生的ZnO-NPs/薯蓣皂苷元）载量为79.972％，ZnO-HLMEA-D载量为39.775％ 1000 （通过掺杂1000 μg mL -1的薯蓣皂苷元溶液产生的ZnO-NPs/薯蓣皂苷元）。 ZnO-HLMEA-D 500和 ZnO-HLMEA-D 1000中的薯蓣皂苷元的溶解度高于游离薯蓣皂苷元的溶解度，证实 ZnO-NPs 具有作为薯蓣皂苷元和可能的其他水不溶性药物的递送载体的潜力。
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