Self‐assembly has proven to be one of the effective methods for the formation of nanoscale therapeutics without the need to use nanodelivery systems. Such minimal models of supramolecular systems formed from amphiphilic photosensitizers (PS) have recently emerged as a new class of photoactive systems, providing unique and in some cases superior activities. Although the mechanism of photogenerated reactive oxygen species (ROS) in such systems is studied and to a certain extent understood, there are very limited studies investigating the influence of intricate environmental factors, including those occurring in the cellular environment, on the self‐assembly and thus the activity of the system. Understanding the optimal conditions for the formation of active PS aggregates is an important area of research in the field of photodynamic therapy (PDT), as it is directly linked to the optimal treatment dose. In this study, we describe the synthesis, self‐assembly properties, photophysical characterization, and photobiological efficacy of structurally closely related low‐symmetry phthalocyanine derivatives. Studying the decay behaviour of the PS fluorescence lifetime in the presence of molecular crowders and different bacterial strains, we found that certain derivatives exhibited adaptive behaviour while others demonstrated non‐adaptive characteristics.

中文翻译：

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跟踪自组装酞菁系统的微环境响应——自适应和非自适应抗菌光敏化


自组装已被证明是形成纳米级治疗药物的有效方法之一，无需使用纳米递送系统。这种由两亲性光敏剂（PS）形成的超分子系统的最小模型最近作为一类新型光敏系统出现，提供了独特的、在某些情况下更优越的活性。尽管人们对此类系统中光生活性氧（ROS）的机制进行了研究并在一定程度上有所了解，但调查复杂环境因素（包括细胞环境中发生的因素）对自组装和组装的影响的研究非常有限。因此系统的活动。了解活性 PS 聚集体形成的最佳条件是光动力疗法 (PDT) 领域的一个重要研究领域，因为它与最佳治疗剂量直接相关。在这项研究中，我们描述了结构密切相关的低对称性酞菁衍生物的合成、自组装特性、光物理表征和光生物学功效。研究在分子拥挤和不同细菌菌株存在下 PS 荧光寿命的衰减行为，我们发现某些衍生物表现出适应性行为，而其他衍生物则表现出非适应性特征。