Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition,Journal of Agricultural and Food Chemistry

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Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2024-07-21 , DOI: 10.1021/acs.jafc.4c02798
Xufeng Li ₁ , Chenyi Gao ₂ , Ke Zhou ₁ , Kaifeng Gan ₁ , Tianjie Ye ₃ , Jun Zhao ₄ , Jin Li ₁ , Chi Ma ₄

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Glucocorticoid-induced osteoporosis (GIOP) is the common reason for secondary osteoporosis. Dendrobine (DEN) is the major biologically active component of Dendrobium officinale with anti-inflammatory and antiaging properties. Whether DEN could alleviate osteogenic inhibition in GIOP rats is still unknown. The influence on osteogenic function caused by DEN on dexamethasone-treated bone marrow mesenchymal stem cells and rats was observed. The in vitro results showed that DEN reversed the inhibition of osteogenic differentiation by dexamethasone. Moreover, DEN supplementation attenuated dexamethasone-induced bone loss in vivo. DEN activated JNK and p38 MAPK pathways and restrained GR nuclear translocation, which could be prevented by the JNK (SP600125) or p38 (SB203580) pathway inhibitor. This study verified that DEN alleviated dexamethasone-induced nuclear translocation of GR, and inhibition of osteogenesis via JNK and p38 pathways, laying the foundation for DEN as a therapeutic agent for GIOP.

中文翻译：

石斛碱通过 JNK/p38 MAPK 通路激活和 GR 核易位抑制促进成骨，从而改善糖皮质激素引起的骨质疏松症

糖皮质激素诱发的骨质疏松症（GIOP）是继发性骨质疏松症的常见原因。石斛碱（DEN）是铁皮石斛的主要生物活性成分，具有抗炎和抗衰老特性。 DEN 是否可以减轻 GIOP 大鼠的成骨抑制尚不清楚。观察DEN对地塞米松处理的骨髓间充质干细胞和大鼠成骨功能的影响。体外结果表明，DEN逆转了地塞米松对成骨分化的抑制作用。此外，补充 DEN 可以减轻地塞米松引起的体内骨质流失。 DEN 激活 JNK 和 p38 MAPK 通路并抑制 GR 核转位，这可以通过 JNK (SP600125) 或 p38 (SB203580) 通路抑制剂来预防。该研究证实DEN减轻了地塞米松诱导的GR核转位，并通过JNK和p38途径抑制成骨，为DEN作为GIOP的治疗药物奠定了基础。

更新日期：2024-07-21

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