Organic polymer coatings have been commonly used in biomedical field, which play an important role in achieving biological antifouling, drug delivery, and bacteriostasis. With the continuous development of polymer science, organic polymer coatings can be designed with complex and advanced functions, which is conducive to the construction of biomedical materials with different performances. According to different physical and chemical properties of materials, biomedical organic polymer coating materials are classified into zwitterionic polymers, non-ionic polymers, and biomacromolecules. The strategies of combining coatings with substrates include physical adsorption, chemical grafting, and self-adhesion. Though the coating materials and construction methods are different, many biomedical polymer coatings have been developed to achieve excellent performances, i.e., enhanced lubrication, anti-inflammation, antifouling, antibacterial, drug release, anti-encrustation, anti-thrombosis, etc. Consequently, a large number of biomedical polymer coatings have been used in artificial lungs, ureteral stent, vascular flow diverter, and artificial joints. In this review, we summarize different types, properties, construction methods, biological functions, and clinical applications of biomedical organic polymer coatings, and prospect future direction for development of organic polymer coatings in biomedical field. It is anticipated that this review can be useful for the design and synthesis of functional organic polymer coatings with various biomedical purposes.

有机聚合物涂层已普遍应用于生物医学领域，在实现生物防污、药物输送、抑菌等方面发挥着重要作用。随着高分子科学的不断发展，有机聚合物涂层可以设计出复杂、先进的功能，有利于构建不同性能的生物医用材料。根据材料物理化学性质的不同，生物医用有机高分子涂层材料分为两性离子聚合物、非离子聚合物和生物大分子。涂层与基材结合的策略包括物理吸附、化学接枝和自粘附。尽管涂层材料和施工方法不同，但目前已开发出多种生物医用高分子涂层，具有增强润滑、抗炎、防污、抗菌、药物缓释、抗结垢、抗血栓等优异性能。生物医用高分子涂层已大量应用于人工肺、输尿管支架、血管分流器、人工关节等领域。本文综述了生物医用有机聚合物涂层的不同类型、性能、构建方法、生物学功能和临床应用，并展望了有机聚合物涂层在生物医学领域的未来发展方向。预计本综述可用于具有各种生物医学用途的功能性有机聚合物涂层的设计和合成。