The G protein Gα13 is frequently lost in germinal center (GC) B cell-derived lymphomas. Mice that lack Gα13 exhibit increased proliferation of GC B cells in gut-draining lymph nodes where they go on to develop lymphomas. Dietary glutamine drives the proliferation of mucosal GC B cells that lack Gα13, potentially explaining the gut tropism of these lymphomas.

中文翻译：

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膳食谷氨酰胺支持粘膜生发中心 B 细胞淋巴瘤


G 蛋白 Gα13 在生发中心 (GC) B 细胞来源的淋巴瘤中经常丢失。缺乏 Gα13 的小鼠肠道引流淋巴结中的 GC B 细胞增殖增加，进而发展为淋巴瘤。膳食谷氨酰胺可促进缺乏 Gα13 的粘膜 GC B 细胞增殖，这可能解释了这些淋巴瘤的肠道趋向性。