<br>紫丁香苷：一种具有药用特性的天然化合物,Frontiers in Pharmacology

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紫丁香苷：一种具有药用特性的天然化合物
Frontiers in Pharmacology ( IF 4.4 ) Pub Date : 2024-07-22 , DOI: 10.3389/fphar.2024.1435524
Qingyuan Qian _{1,

2} , Jinchao Pan _{2,

3} , Jun Yang _{2,

4} , Renjie Wang _{2,

4} , Kai Luo _{2,

4} , Zhenhui Wu ₂ , Shuhe Ma _{2,

4} , Yuguang Wang ₂ , Maoxing Li _{1,

2,

4} , Yue Gao _{2,

3}

Affiliation

紫丁香苷是一种苯丙素苷，广泛分布于多种植物中，例如刺五加（Rupr. et Maxim.）危害，丁香(BL) 原变种。曼德苏里卡（Maxim.）Hara，和圆形冬青拇指。它是众多上市药品、保健品、食品的主要成分，具有免疫调节、抗肿瘤、降血糖、降血脂等作用。本文旨在系统总结紫丁香苷的理化性质、植物来源、提取分离方法、全合成方法、药理活性、药物安全性以及制备和应用等。它还将涵盖丁香苷的药代动力学，然后对未来的应用前景提出建议。有关紫丁香苷的信息通过互联网（PubMed、CNKI、Google Scholar、百度学术、Web of Science、Medline Plus、ACS Elsevier 和 Flora of China）和图书馆从国际公认的科学数据库中获取。选择丁香苷、提取分离、药理活性、制备与应用、药代动力学为关键词。据统计，紫丁香苷存在于23科60余属、100多种植物中。丁香苷作为多种中草药的关键成分，因其独特的芥子醇结构而具有重要的研究价值。其多种药理作用包括免疫调节活性、肿瘤抑制、降血糖作用和降血脂作用。此外，它已被证明可以提供神经保护、肝脏保护、辐射保护、心脏保护和骨骼保护。相关制剂如艾迪注射液、复方斑蝥素胶囊、痰热清注射液等已广泛应用于临床。关于丁香苷的其他研究，如提取和分离、全合成、安全性评估和药代动力学也取得了进展。深入探讨其作用机制对于医学研究尤其是免疫和肿瘤治疗至关重要。同时，要加大力度支持提高植物资源利用率，开发适应工业生化需要的提取手段，在保障人民健康的同时进一步促进经济发展。

"点击查看英文标题和摘要"

Syringin: a naturally occurring compound with medicinal properties

Syringin, a phenylpropanoid glycoside, is widely distributed in various plants, such as Acanthopanax senticosus (Rupr. et Maxim.) Harms, Syringa reticulata (BL) Hara var. mandshurica (Maxim.) Hara, and Ilex rotunda Thumb. It serves as the main ingredient in numerous listed medicines, health products, and foods with immunomodulatory, anti-tumor, antihyperglycemic, and antihyperlipidemic effects. This review aims to systematically summarize syringin, including its physicochemical properties, plant sources, extraction and separation methods, total synthesis approaches, pharmacological activities, drug safety profiles, and preparations and applications. It will also cover the pharmacokinetics of syringin, followed by suggestions for future application prospects. The information on syringin was obtained from internationally recognized scientific databases through the Internet (PubMed, CNKI, Google Scholar, Baidu Scholar, Web of Science, Medline Plus, ACS Elsevier, and Flora of China) and libraries. Syringin, extraction and separation, pharmacological activities, preparations and applications, and pharmacokinetics were chosen as the keywords. According to statistics, syringin can be found in 23 families more than 60 genera, and over 100 species of plants. As a key component in many Chinese herbal medicines, syringin holds significant research value due to its unique sinapyl alcohol structure. Its diverse pharmacological effects include immunomodulatory activity, tumor suppression, hypoglycemic action, and hypolipidemic effects. Additionally, it has been shown to provide neuroprotection, liver protection, radiation protection, cardioprotection, and bone protection. Related preparations such as Aidi injection, compound cantharidin capsule, and Tanreqing injection have been widely used in clinical settings. Other studies on syringin such as extraction and isolation, total synthesis, safety profile assessment, and pharmacokinetics have also made progress. It is crucial for medical research to deeply explore its mechanism of action, especially regarding immunity and tumor therapy. Meanwhile, more robust support is needed to improve the utilization of plant resources and to develop extraction means adapted to the needs of industrial biochemistry to further promote economic development while protecting people’s health.

更新日期：2024-07-22

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