<br>NEUROD1：人类和小鼠神经元和内分泌细胞谱系程序的转录和表观遗传调节因子,Frontiers in Cell and Developmental Biology

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NEUROD1：人类和小鼠神经元和内分泌细胞谱系程序的转录和表观遗传调节因子
Frontiers in Cell and Developmental Biology ( IF 4.6 ) Pub Date : 2024-07-22 , DOI: 10.3389/fcell.2024.1435546
Gabriela Pavlinkova ₁ , Ondrej Smolik ₁

Affiliation

属于基本螺旋-环-螺旋 (bHLH) 家族的转录因子是发育过程中细胞命运规范和分化的关键调节因子。它们的失调不仅与发育异常有关，还与各种成人疾病和癌症有关。最近，bHLH 因子的能力已被用于细胞替代疗法的重编程策略。 NEUROD1 就是这样的因子之一，它与表观遗传景观的重新编程有关，并可能具有先驱因子的能力，启动神经元发育程序，并强制胰腺内分泌分化。该综述旨在巩固目前关于 NEUROD1 在人类和小鼠细胞分化和重编程中的多方面作用和机制途径的知识，探索 NEUROD1 在指导神经内分泌细胞谱系的发育和重编程中的作用。该综述重点关注 NEUROD1 的分子机制、其与其他转录因子的相互作用、其作为染色质重塑先锋因子的作用以及其在细胞重编程中的潜力。我们还展示了 NEUROD1 在神经元和胰腺内分泌细胞分化中的差异潜力，强调了其治疗潜力以及进一步研究以充分理解和利用其功能的必要性。

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NEUROD1: transcriptional and epigenetic regulator of human and mouse neuronal and endocrine cell lineage programs

Transcription factors belonging to the basic helix-loop-helix (bHLH) family are key regulators of cell fate specification and differentiation during development. Their dysregulation is implicated not only in developmental abnormalities but also in various adult diseases and cancers. Recently, the abilities of bHLH factors have been exploited in reprogramming strategies for cell replacement therapy. One such factor is NEUROD1, which has been associated with the reprogramming of the epigenetic landscape and potentially possessing pioneer factor abilities, initiating neuronal developmental programs, and enforcing pancreatic endocrine differentiation. The review aims to consolidate current knowledge on NEUROD1’s multifaceted roles and mechanistic pathways in human and mouse cell differentiation and reprogramming, exploring NEUROD1 roles in guiding the development and reprogramming of neuroendocrine cell lineages. The review focuses on NEUROD1’s molecular mechanisms, its interactions with other transcription factors, its role as a pioneer factor in chromatin remodeling, and its potential in cell reprogramming. We also show a differential potential of NEUROD1 in differentiation of neurons and pancreatic endocrine cells, highlighting its therapeutic potential and the necessity for further research to fully understand and utilize its capabilities.

更新日期：2024-07-22

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