Desorption Electrospray Ionization Mass Spectrometry Imaging of Powder-Treated Fingermarks on Forensic Gelatin Lifters and its Application for Separating Overlapping Fingermarks,Analytical Chemistry

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Desorption Electrospray Ionization Mass Spectrometry Imaging of Powder-Treated Fingermarks on Forensic Gelatin Lifters and its Application for Separating Overlapping Fingermarks
Analytical Chemistry ( IF 6.7 ) Pub Date : 2024-07-19 , DOI: 10.1021/acs.analchem.4c02305
Kim Frisch ₁ , Kirstine L. Nielsen ₁ , Jo̷rgen B. Hasselstro̷m ₁ , Rikke Fink ₂ , Stine V. Rasmussen ₂ , Mogens Johannsen ₁

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Fingermarks are frequently collected at crime scenes by using gelatin lifters for preservation and transport of the marks to a forensic laboratory for inspection. The gelatin lifters preserve both the imprint of the fingermark pattern necessary for identification purposes and the chemical residue of the mark potentially useful for profiling the person who left the fingermark. The fingermark patterns are traditionally recorded using photography/optical imaging, but methods for chemical analysis of fingermark residues on gelatin lifters are scarce. Here we report the first method for the chemical analysis of fingermarks on gelatin lifters using desorption electrospray ionization mass spectrometry (DESI-MS) imaging. The imaging can be done directly on the gelatin support without any sample preparation, supporting immediate operational use of the method for fingermarks collected at crime scenes. Operational use of the method is further supported by successful chemical imaging of fingermarks enhanced by traditional dusting with forensic powders and lifted off different surfaces (glass, stainless steel, painted aluminum, polystyrene, cardboard, and plastic) as well as fingermarks lifted multiple times. We also demonstrate that the present method can be used to visually separate natural overlapping powder-treated fingermarks, and the chemical composition of the fingermarks can be analyzed on the gelatin support by DESI-MS/MS. The presented method has potential for integration into the traditional workflow for fingermark analysis, and will allow more fingermarks collected at crime scenes to be evaluated both visually and chemically.

中文翻译：

法医明胶提升器上粉末处理指纹的解吸电喷雾电离质谱成像及其在分离重叠指纹中的应用

经常使用明胶提升器在犯罪现场收集指纹，以保存指纹并将其运送到法医实验室进行检查。明胶剥离器既保留了识别所需的指纹图案印记，又保留了可能有助于分析留下指纹的人的化学残留物。传统上使用摄影/光学成像记录指纹图案，但对明胶提升器上的指纹残留物进行化学分析的方法很少。在这里，我们报告了第一种使用解吸电喷雾电离质谱 (DESI-MS) 成像对明胶提升器上的指纹进行化学分析的方法。成像可以直接在明胶支持物上完成，无需任何样品制备，支持立即使用该方法在犯罪现场收集的指纹。该方法的操作使用得到了成功的指纹化学成像的进一步支持，该指纹通过传统的法医粉末撒粉和从不同表面（玻璃、不锈钢、涂漆铝、聚苯乙烯、纸板和塑料）上剥离以及多次剥离的指纹进行增强。我们还证明，本方法可用于视觉上分离天然重叠的粉末处理的指纹，并且可以通过 DESI-MS/MS 在明胶支持物上分析指纹的化学成分。所提出的方法有可能集成到指纹分析的传统工作流程中，并将允许对在犯罪现场收集的更多指纹进行视觉和化学评估。

更新日期：2024-07-19

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