Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway,ACS Omega

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Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway
ACS Omega ( IF 3.7 ) Pub Date : 2024-07-16 , DOI: 10.1021/acsomega.4c03738
Hong Duan _{1,

2} , Han Li _{1,

2} , Tianyi Liu ₁ , Yuan Chen _{1,

2} , Mengmeng Luo _{1,

2} , Ying Shi _{1,

2} , Jing Zhou _{1,

2} , Marwan M A Rashed ₁ , Kefeng Zhai _{1,

2} , Lili Li ₃ , Zhaojun Wei ₄

Affiliation

Atherosclerosis (AS) is a common cardiovascular disease that poses a major threat to health. Schisandra chinensis is a medicinal and edible plant that is commonly used to treat cardiovascular diseases. In this paper, HPLC was used to detect and analyze 5 different components in Schisandra chinensis. Network pharmacological predictions highlight the PI3K/AKT/mTOR pathway as an important pharmacological pathway. The effective ingredient Schisandrin C was screened by the molecular docking technique. ox-LDL-induced HUVECs were used to construct the atherosclerosis model for further experimental verification. The results showed that Schisandrin C interfered with the PI3K/AKT/mTOR autophagy pathway. This study lays a foundation for the further application of Schisandrin C in the prevention and treatment of atherosclerosis in the future.

中文翻译：

探讨五味子C通过PI3K/AKT/mTOR自噬途径治疗动脉粥样硬化的分子机制

动脉粥样硬化（AS）是一种常见的心血管疾病，对健康构成重大威胁。五味子是一种药食两用植物，常用于治疗心血管疾病。本文采用高效液相色谱法对五味子中的5种不同成分进行检测分析。网络药理学预测强调 PI3K/AKT/mTOR 通路是一条重要的药理学通路。采用分子对接技术筛选有效成分五味子C。 ox-LDL诱导的HUVEC用于构建动脉粥样硬化模型以供进一步的实验验证。结果表明五味子C干扰PI3K/AKT/mTOR自噬通路。该研究为今后进一步应用五味子C防治动脉粥样硬化奠定了基础。

更新日期：2024-07-16

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