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Synthesis, Characterization and Biological Evaluation of 3-Oxo-Pyrimido[1,2-b]indazoles
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-07-20 , DOI: 10.1002/adsc.202400739 Xinyu Zhang 1 , Xuan Zhao 1 , Die Wu 2 , Jingsa Zhang 2 , Yilu Shou 2 , Xingya Wang 2 , Yongmin Ma 1 , Bihong Zhu 3
中文翻译：
3-氧代吡啶并[1,2-b]吲哚唑的合成、表征和生物学评价
更新日期：2024-07-20
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2024-07-20 , DOI: 10.1002/adsc.202400739 Xinyu Zhang 1 , Xuan Zhao 1 , Die Wu 2 , Jingsa Zhang 2 , Yilu Shou 2 , Xingya Wang 2 , Yongmin Ma 1 , Bihong Zhu 3
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The synthesis of substituted 3-oxo-pyrimido[1,2-b]indazoles from 3-aminoindazoles and ketones has been established. It involves one molecule of 3-aminoindazoles and two molecules of ketones via a [3+2+1] three-component annulation process. 3-Oxo-pyrimido[1,2-b]indazoles exhibit strong yellow fluorescence in various solvents. A wide range of products have anti-oxidant activities. Cytotoxicity studies indicate that compounds 3 a, 3 aa and 3 ab have obvious effects on both HCT116 and A549 cancer cell lines.
中文翻译：
3-氧代吡啶并[1,2-b]吲哚唑的合成、表征和生物学评价
已经建立了从 3-氨基吲哚唑和酮合成取代的 3-氧代嘧啶[1,2-b] 吲哚唑。它涉及一个 3-氨基吲哚唑分子和两个酮分子，通过 [3+2+1] 三组分环化过程。3-氧代嘧啶[1,2-b]吲哚唑在各种溶剂中表现出强烈的黄色荧光。许多产品具有抗氧化活性。细胞毒性研究表明，化合物 3 a、3 aa 和 3 ab 对 HCT116 和 A549 癌细胞系均有明显影响。
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