Green Synthesis of Alzheimer′s Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis,ChemSusChem

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Green Synthesis of Alzheimer′s Disease Probes Aftobetin and Analogues Enabled by Flow Technology and Heterogeneous Photocatalysis
ChemSusChem ( IF 7.5 ) Pub Date : 2024-07-19 , DOI: 10.1002/cssc.202401214
Yongjiu Li ₁ , Xin Liu ₂ , Qiong Liu ₃ , Yuchen Wang ₂ , Fener Chen ₄ , Chenguang Liu ₅

Affiliation

Flow synthesis and heterogeneous photocatalysis were integrated to develop a fully-flow synthesis protocol of AD probe aftobetin. This process featured the heterogeneous photo-air oxidation replacing toxic chromium oxidation, heterogeneous photo-nickel C−N coupling replacing noble palladium catalysis, a modified esterification to circumvent the difficult-to-remove dicyclohexylurea. Furthermore, C−N coupling, esterification and Knoevenagel condensation were telescoped together to simplify workup and purification.

中文翻译：

利用流动技术和多相光催化绿色合成阿尔茨海默病探针 Aftobetin 及其类似物

将流动合成和异相光催化相结合，开发了 AD 探针 aftobetin 的全流动合成方案。该过程的特点是用多相光空气氧化取代有毒的铬氧化，用多相光镍CN耦合取代贵重钯催化，并改进酯化以避免难以去除的二环己基脲。此外，CN 偶联、酯化和 Knoevenagel 缩合被组合在一起，以简化后处理和纯化。

更新日期：2024-07-19

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