Flow synthesis and heterogeneous photocatalysis were integrated to develop a fully-flow synthesis protocol of AD probe aftobetin. This process featured the heterogeneous photo-air oxidation replacing toxic chromium oxidation, heterogeneous photo-nickel C−N coupling replacing noble palladium catalysis, a modified esterification to circumvent the difficult-to-remove dicyclohexylurea. Furthermore, C−N coupling, esterification and Knoevenagel condensation were telescoped together to simplify workup and purification.

中文翻译：

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利用流动技术和多相光催化绿色合成阿尔茨海默病探针 Aftobetin 及其类似物


将流动合成和异相光催化相结合，开发了 AD 探针 aftobetin 的全流动合成方案。该过程的特点是用多相光空气氧化取代有毒的铬氧化，用多相光镍CN耦合取代贵重钯催化，并改进酯化以避免难以去除的二环己基脲。此外，CN 偶联、酯化和 Knoevenagel 缩合被组合在一起，以简化后处理和纯化。