Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols,Nature Communications

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Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols
Nature Communications ( IF 14.7 ) Pub Date : 2024-07-20 , DOI: 10.1038/s41467-024-50596-3
Jia Xu ₁ , Yilin Liu ₁ , Qing Wang ₁ , Xiangzhang Tao ₁ , Shengyang Ni ₁ , Weigang Zhang ₁ , Lei Yu ₁ , Yi Pan ₁ , Yi Wang ₁

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Alkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions. A range of primary, secondary, and tertiary alkylamines are obtained. This practical procedure can be scaled up through electrochemical continuous flow technique.

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