OBJECTIVE To evaluate whether associations between sitting time and all-cause and heart disease mortality are modified by physical activity in adults with diabetes. RESEARCH DESIGN AND METHODS Data came from 6,335 U.S. adults with diabetes from National Health and Nutrition Examination Survey 2007–2018 (baseline), with mortality follow-up through 2019. Sitting time and moderate to vigorous physical activity (MVPA) were self-reported. Cox models were adjusted for sociodemographics, lifestyle factors, and medical conditions. RESULTS Over a median follow-up of 5.9 years, 1,278 all-cause and 354 heart disease deaths were documented (mean age, 59.6 years; 48.3% female). Longer sitting time was associated with greater all-cause and heart disease mortality risk in inactive (MVPA <10 min/week) or insufficiently active (MVPA 10 to <150 min/week) adults with diabetes, but not in active adults (MVPA ≥150 min/week) (all-cause mortality: P = 0.003 for interaction; heart disease mortality: P = 0.008 for interaction). CONCLUSIONS In adults with diabetes, meeting guideline-recommended physical activity may offset the elevated all-cause and heart disease mortality risk associated with excessive sitting time.

中文翻译：

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坐着时间及其与体力活动的相互作用与美国成人糖尿病患者全因死亡率和心脏病死亡率的关系


目的 评估成人糖尿病患者的体力活动是否会改变久坐时间与全因死亡率和心脏病死亡率之间的关联。研究设计和方法 数据来自 2007 年至 2018 年国家健康和营养检查调查（基线）中的 6,335 名美国糖尿病成人，并进行了 2019 年死亡率随访。坐姿时间和中度至剧烈体力活动 (MVPA) 是自我报告的。 Cox 模型根据社会人口统计、生活方式因素和医疗条件进行了调整。结果 在中位随访 5.9 年中，记录了 1,278 例全因死亡和 354 例心脏病死亡（平均年龄 59.6 岁；48.3% 为女性）。对于不活动（MVPA <10 分钟/周）或活动不足（MVPA 10 至 <150 分钟/周）的成年糖尿病患者，坐姿时间越长与全因死亡风险和心脏病死亡风险越高相关，但对于活跃的成人（MVPA ≥ 150 分钟/周）（全因死亡率：交互作用 P = 0.003；心脏病死亡率：交互作用 P = 0.008）。结论 对于成人糖尿病患者，进行指南建议的体力活动可能会抵消因久坐时间过长而导致的全因死亡率和心脏病死亡率升高的风险。