Within a multi-state viral genomic surveillance program, we evaluated whether proportions of SARS-CoV-2 infections attributed to the JN.1 variant and to XBB-lineage variants (including HV.1 and EG.5) differed between inpatient and outpatient care settings during periods of cocirculation. Both JN.1 and HV.1 were less likely than EG.5 to account for infections among inpatients versus outpatients (aOR=0.60 [95% CI: 0.43-0.84; p=0.003] and aOR=0.35 [95% CI: 0.21-0.58; p<0.001], respectively). JN.1 and HV.1 variants may be associated with a lower risk of severe illness. The severity of COVID-19 may have attenuated as predominant circulating SARS-CoV-2 lineages shifted from EG.5 to HV.1 to JN.1.

中文翻译：

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与 EG.5 变体相比，JN.1 或 HV.1 SARS-CoV-2 变体住院的可能性降低


在多州病毒基因组监测计划中，我们评估了住院患者和门诊患者中 JN.1 变体和 XBB 谱系变体（包括 HV.1 和 EG.5）引起的 SARS-CoV-2 感染比例是否存在差异共循环期间的设置。 JN.1 和 HV.1 都比 EG.5 更不可能解释住院患者与门诊患者之间的感染（aOR=0.60 [95% CI: 0.43-0.84; p=0.003] 和 aOR=0.35 [95% CI: 0.21]分别为-0.58；p<0.001]。 JN.1 和 HV.1 变异可能与较低的严重疾病风险相关。随着主要循环 SARS-CoV-2 谱系从 EG.5 转变为 HV.1 再到 JN.1，COVID-19 的严重程度可能有所减弱。