Within a multistate viral genomic surveillance program, we evaluated whether proportions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections attributed to the JN.1 variant and to XBB-lineage variants (including HV.1 and EG.5) differed between inpatient and outpatient care settings during periods of cocirculation. Both JN.1 and HV.1 were less likely than EG.5 to account for infections among inpatients versus outpatients (adjusted odds ratio [aOR], 0.60 [95% confidence interval (CI), .43–.84; P = .003] and 0.35 [.21–.58; P < .001], respectively). JN.1 and HV.1 variants may be associated with a lower risk of severe illness. The severity of coronavirus disease 2019 may have attenuated as predominant circulating SARS-CoV-2 lineages shifted from EG.5 to HV.1 to JN.1.

中文翻译：

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与 EG.5 变体相比，JN.1 或 HV.1 严重急性呼吸系统综合症冠状病毒 2 变体住院的可能性降低


在多状态病毒基因组监测计划中，我们评估了归因于 JN.1 变体和 XBB 谱系变体（包括 HV.1 和 EG.5）的严重急性呼吸系统综合症冠状病毒 2 （SARS-CoV-2） 感染的比例在共循环期间在住院和门诊护理环境中是否不同。JN.1 和 HV.1 比 EG.5 更不可能解释住院患者与门诊患者的感染（调整后比值比 [aOR]，0.60 [95% 置信区间 （CI），.43–.84;P = .003] 和 0.35 [.21–.58;P < .001]。JN.1 和 HV.1 变体可能与较低的重症风险有关。随着主要流行的 SARS-CoV-2 谱系从 EG.5 转移到 HV.1 再到 JN.1,2019 冠状病毒病的严重程度可能已经减弱。