Dynamic Cross-Linking, Self-Healing, Antibacterial Hydrogel for Regenerating Irregular Cranial Bone Defects,ACS Applied Materials & Interfaces

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Dynamic Cross-Linking, Self-Healing, Antibacterial Hydrogel for Regenerating Irregular Cranial Bone Defects
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2024-07-18 , DOI: 10.1021/acsami.4c07057
Zuoxiang Dong ₁ , Jian Xu ₁ , Peng Lun ₁ , Zeyu Wu ₁ , Wenshuai Deng ₁ , Peng Sun ₁

Affiliation

Given the widespread clinical demand, addressing irregular cranial bone defects poses a significant challenge following surgical procedures and traumatic events. In situ-formed injectable hydrogels are attractive for irregular bone defects due to their ease of administration and the ability to incorporate ceramics, ions, and proteins into the hydrogel. In this study, a multifunctional hydrogel composed of oxidized sodium alginate (OSA)-grafted dopamine (DO), carboxymethyl chitosan (CMCS), calcium ions (Ca²⁺), nanohydroxyapatite (nHA), and magnesium oxide (MgO) (DOCMCHM) was prepared to address irregular cranial bone defects via dynamic Schiff base and chelation reactions. DOCMCHM hydrogel exhibits strong adhesion to wet tissues, self-healing properties, and antibacterial characteristics. Biological evaluations indicate that DOCMCHM hydrogel has good biocompatibility, in vivo degradability, and the ability to promote cell proliferation. Importantly, DOCMCHM hydrogel, containing MgO, promotes the expression of osteogenic protein markers COL-1, OCN, and RUNX2, and stimulates the formation of new blood vessels by upregulating CD31. This study could provide meaningful insights into ion therapy for the repair of cranial bone defects.

中文翻译：

用于再生不规则颅骨缺损的动态交联、自愈、抗菌水凝胶

鉴于广泛的临床需求，解决不规则颅骨缺损在外科手术和创伤事件后提出了重大挑战。原位形成的可注射水凝胶对于不规则骨缺损很有吸引力，因为它们易于给药并且能够将陶瓷、离子和蛋白质掺入水凝胶中。在这项研究中，由氧化海藻酸钠（OSA）接枝多巴胺（DO）、羧甲基壳聚糖（CMCS）、钙离子（Ca ²⁺ ）、纳米羟基磷灰石（nHA）和氧化镁（MgO）（DOCMCHM）组成的多功能水凝胶准备通过动态希夫碱和螯合反应来解决不规则颅骨缺损。 DOCMCHM水凝胶对湿组织具有很强的粘附力、自修复特性和抗菌特性。生物学评价表明DOCMCHM水凝胶具有良好的生物相容性、体内可降解性以及促进细胞增殖的能力。重要的是，含有 MgO 的 DOCMCHM 水凝胶可促进成骨蛋白标记物 COL-1、OCN 和 RUNX2 的表达，并通过上调 CD31 刺激新血管的形成。这项研究可以为修复颅骨缺损的离子疗法提供有意义的见解。

更新日期：2024-07-18

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