Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS-CoV-2 Variants,Angewandte Chemie International Edition

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Spatial Engineering of Heterotypic Antigens on a DNA Framework for the Preparation of Mosaic Nanoparticle Vaccines with Enhanced Immune Activation against SARS-CoV-2 Variants
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-07-18 , DOI: 10.1002/anie.202412294
Yang Yang ₁ , Jialu Zhang ₂ , Yunyun Xu ₃ , Mingying Chen ₂ , Shengwen Wang ₄ , Guihong Lin ₂ , Yihao Huang ₂ , Chaoyong Yang ₂ , Yanling Song ₂

Affiliation

A DNA nanotechnology-based strategy for spatially assembling heterotypic antigens (hetero-POINT) has been developed to rationalize the design of mosaic nanoparticle vaccines. Immunological investigations reveal that the pattern of heterotypic antigen distribution yields distinct humoral and mucosal immune effects, highlighting the significance of the spatial placement of the antigens in structure–activity relationships.

中文翻译：

DNA 框架上异型抗原的空间工程，用于制备针对 SARS-CoV-2 变体的增强免疫激活的马赛克纳米颗粒疫苗

已经开发了一种基于 DNA 纳米技术的空间组装异型抗原（hetero-POINT）策略，以合理化镶嵌纳米颗粒疫苗的设计。免疫学研究表明，异型抗原分布模式产生不同的体液和粘膜免疫效应，突出了抗原空间位置在结构-活性关系中的重要性。

更新日期：2024-07-18

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