Prenatal Parental Exposure to Metals and Birth Defects: A Prospective Birth Cohort Study,Environmental Science & Technology

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Prenatal Parental Exposure to Metals and Birth Defects: A Prospective Birth Cohort Study
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2024-07-17 , DOI: 10.1021/acs.est.4c01945
Hong Lv _{1,

2,

3} , Yangqian Jiang _{1,

4} , Kan Ye ₅ , Jinghan Wang _{1,

4} , Weiting Wang _{1,

4} , Jiangbo Du _{1,

2,

3} , Lingmin Hu _{1,

6} , Wenhui Guo _{1,

2} , Rui Qin _{1,

4} , Xin Xu _{1,

4} , Yuanyan Dou _{1,

2} , Tianyu Sun _{1,

2} , Xiaoyu Liu _{1,

2} , Bo Xu _{1,

2} , Xiumei Han _{1,

2} , Kun Zhou _{1,

2} , Shiyao Tao _{1,

2} , Qun Lu _{1,

4} , Tao Jiang _{1,

7} , Yang Zhao _{1,

7} , Guangfu Jin _{1,

2,

3} , Hongxia Ma _{1,

2,

3} , Yankai Xia _{1,

8} , Jiong Li _{1,

2} , Hongbing Shen _{1,

2,

3} , Xia Chi ₉ , Yuan Lin _{1,

3,

4} , Zhibin Hu _{1,

2,

3} , Jiangsu Birth Cohort Jbc Study Group

Affiliation

State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China.
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China.
Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Child Health Care, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215002, China.
Department of Reproduction, Changzhou Maternity and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, China.
Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China.
Department of Child Health Care, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China.

While maternal exposure to high metal levels during pregnancy is an established risk factor for birth defects, the role of paternal exposure remains largely unknown. We aimed to assess the associations of prenatal paternal and maternal metal exposure and parental coexposure with birth defects in singletons. This study conducted within the Jiangsu Birth Cohort recruited couples in early pregnancy. We measured their urinary concentrations for 25 metals. A total of 1675 parent–offspring trios were included. The prevalence of any birth defects among infants by one year of age was 7.82%. Paternal-specific gravity-corrected urinary concentrations of titanium, vanadium, chromium, manganese, cobalt, nickel, copper, and selenium and maternal vanadium, chromium, nickel, copper, selenium, and antimony were associated with a 21–91% increased risk of birth defects after adjusting for covariates. These effects persisted after mutual adjustment for the spouse’s exposure. Notably, when assessing the parental mixture effect by Bayesian kernel machine regression, paternal and maternal chromium exposure ranked the highest in relative importance. Parental coexposure to metal mixture showed a pronounced joint effect on the risk of overall birth defects, as well as for some specific subtypes. Our findings suggested a couple-based prevention strategy for metal exposure to reduce birth defects in offspring.

中文翻译：

产前父母接触金属和出生缺陷：一项前瞻性出生队列研究

虽然母亲在怀孕期间接触高金属水平是出生缺陷的一个确定的危险因素，但父亲接触的作用仍然很大程度上未知。我们的目的是评估产前父亲和母亲金属暴露以及父母共同暴露与单胎出生缺陷的关联。这项研究在江苏出生队列中招募了怀孕早期的夫妇。我们测量了他们尿液中 25 种金属的浓度。总共包括 1675 个亲子三人组。一岁以下婴儿出生缺陷的发生率为 7.82%。经父亲比重校正的尿中钛、钒、铬、锰、钴、镍、铜和硒浓度以及母体钒、铬、镍、铜、硒和锑的浓度与患妊娠风险增加 21-91% 相关。调整协变量后的出生缺陷。在对配偶的暴露进行相互调整后，这些影响仍然存在。值得注意的是，当通过贝叶斯核机器回归评估亲本混合效应时，父本和母本铬暴露的相对重要性排名最高。父母共同接触金属混合物对整体出生缺陷以及某些特定亚型的风险有显着的联合影响。我们的研究结果提出了基于夫妇的金属暴露预防策略，以减少后代的出生缺陷。

更新日期：2024-07-17

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