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STX-bpc: “Brightening” the path to neuronal inhibition
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-07-18 , DOI: 10.1016/j.chembiol.2024.06.008 Jinxia Wan 1 , Yulong Li 2
中文翻译:
STX-bpc:“照亮”神经元抑制之路
更新日期:2024-07-19
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2024-07-18 , DOI: 10.1016/j.chembiol.2024.06.008 Jinxia Wan 1 , Yulong Li 2
Affiliation
In this issue of Cell Chemical Biology, Elleman et al.1 introduce a transformative chemical approach to control neuronal activity with high spatial and temporal resolution. The authors present STX-bpc, a potent neurotoxin that naturally inhibits voltage-gated sodium channels (NaVs), complementing available optogenetic methods for manipulating neuronal activity, cellular communication, and behavior.
中文翻译:
STX-bpc:“照亮”神经元抑制之路
在本期《细胞化学生物学》中,Elleman 等人。 1介绍一种变革性化学方法,以高空间和时间分辨率控制神经元活动。作者提出了 STX-bpc,一种强效神经毒素,可自然抑制电压门控钠通道 (Na V s),补充了用于操纵神经元活动、细胞通讯和行为的现有光遗传学方法。