In this issue of Cell Chemical Biology, Kim et al.¹ present a novel optogenetic tool, opto-PLCβ, to control PLCβ signaling optically. In addition to eliciting PIP2 hydrolysis and downstream signaling in cells, opto-PLCβ also enabled probing the impact of PLCβ signaling on amygdala synaptic plasticity and fear learning in mice.

中文翻译：

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PLCβ 的新曙光！

在本期《细胞化学生物学》中，Kim 等人1 提出了一种新的光遗传学工具 opto-PLCβ，用于光学控制 PLCβ 信号传导。除了在细胞中引发 PIP2 水解和下游信号传导外，opto-PLCβ 还能够探测 PLCβ 信号传导对小鼠杏仁核突触可塑性和恐惧学习的影响。