Background The transmission dynamics of hepatitis E in men who have sex with men (MSM) are poorly understood. We aimed to explore any factors observed in MSM with hepatitis E by systematically reviewing the literature. Methods We searched five databases (PubMed, Embase, CINAHL Plus, MEDLINE and Web of Science Core Collections). The primary author performed an initial screen of citations and abstracts, and two authors independently reviewed full-text manuscripts for eligibility. We only included manuscripts in English that explored at least one risk factor for hepatitis E. The risk of bias was assessed using the Joanna Briggs Institute toolkits. Narrative data were synthesised and tabulated. This review was registered on PROSPERO (ID: CRD42023472303). Results 14 manuscripts were included in this review: two case reports, one case-control study, two cohort studies and nine cross-sectional studies from Italy (n=3), Japan (n=2), France (n=2), Argentina (n=1), Russia (n=1), the USA (n=1), the Netherlands (n=1), Belgium (n=1), Spain (n=1) and Greece (n=1). In total, there were 376 MSM with hepatitis E in this analysis. We have highlighted demographic (bimodal age (16–29 and >40), HIV pre-exposure prophylaxis use, living with HIV) and biological (previous syphilis, hepatitis C and hepatitis A) factors in MSM with previous/current hepatitis E. In five manuscripts, no association was found between MSM and hepatitis E. Conclusion Despite conflicting data, hepatitis E may be sexually transmissible in MSM, and MSM with unexplained jaundice, transaminitis, renal disease or neurological disease should be tested. HIV, hepatitis A (including vaccination), hepatitis C and syphilis testing are required in MSM with hepatitis E. This review provides some insight for future clinical guidelines, public health outbreak control strategies and research. Data sharing not applicable to this article as no datasets were generated or analysed during the current study. All data relevant to the study are included in the article

中文翻译：

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男男性行为者的戊型肝炎：系统评价


背景 人们对男男性行为者 (MSM) 中戊型肝炎的传播动态知之甚少。我们旨在通过系统回顾文献来探讨在患有戊型肝炎的 MSM 中观察到的任何因素。方法 我们检索了五个数据库（PubMed、Embase、CINAHL Plus、MEDLINE 和 Web of Science 核心合集）。主要作者对引文和摘要进行了初步筛选，两位作者独立审查了全文稿件的资格。我们只收录了探讨至少一种戊型肝炎危险因素的英文手稿。使用乔安娜·布里格斯研究所工具包评估偏倚风险。叙述数据被综合并制成表格。该评论已在 PROSPERO 上注册（ID：CRD42023472303）。结果 本次综述纳入了 14 份手稿：两份病例报告、一份病例对照研究、两项队列研究和九份横断面研究，来自意大利 (n=3)、日本 (n=2)、法国 (n=2)、阿根廷 (n=1)、俄罗斯 (n=1)、美国 (n=1)、荷兰 (n=1)、比利时 (n=1)、西班牙 (n=1) 和希腊 (n=1) 。此次分析中总共有 376 名 MSM 患有戊型肝炎。我们强调了患有既往/当前戊型肝炎的 MSM 中的人口统计学（双峰年龄（16-29 和 >40）、HIV 暴露前预防使用、HIV 感染者）和生物学（既往梅毒、丙型肝炎和甲型肝炎）因素。 5 篇手稿中，没有发现 MSM 与戊型肝炎之间存在关联。结论 尽管数据存在矛盾，但 MSM 中戊型肝炎可能通过性传播，患有不明原因黄疸、转氨炎、肾脏疾病或神经系统疾病的 MSM 应进行检测。患有戊型肝炎的 MSM 需要进行 HIV、甲型肝炎（包括疫苗接种）、丙型肝炎和梅毒检测。 这篇综述为未来的临床指南、公共卫生疫情控制策略和研究提供了一些见解。数据共享不适用于本文，因为当前研究期间没有生成或分析数据集。与该研究相关的所有数据均包含在文章中