With great interest, we have read the recent article “Expression of HIF1α in intestinal epithelium restricts arthritis inflammation by inhibiting RIPK3-induced cell death machinery” published by Lyu et al. in Annals of the Rheumatic Diseases. The authors pose that the expression of hypoxia-inducible factor 1 alpha in intestinal epithelial cells represents a crucial check point for the development of arthritis by impeding necroptosis of intestinal epithelial cells and safeguarding the intestinal barrier integrity. Previous studies suggest a potential mechanistic link between faulty intestinal barrier function and potentiation of arthritogenic immune cells. From this perspective, bolstering the intestinal barrier integrity arose as an attractive therapeutic strategy for rheumatoid arthritis.

中文翻译：

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稳定肠道屏障的完整性以控制关节炎


我们怀着极大的兴趣阅读了Lyu等人最近发表的文章“Expression of HIF1α in Entertal Epithelium Limits Arthritis Inflammation by Preventing RIPK3-induced Cell Death Machinery”。在风湿病年鉴中。作者提出，肠上皮细胞中缺氧诱导因子 1 α 的表达通过阻止肠上皮细胞坏死性凋亡和维护肠屏障完整性，成为关节炎发生的关键检查点。先前的研究表明，肠道屏障功能缺陷与致关节炎免疫细胞的增强之间存在潜在的机制联系。从这个角度来看，增强肠道屏障的完整性成为类风湿关节炎的一种有吸引力的治疗策略。