Fructooligosaccharides Ameliorate Renal Injury and Dysfunction Through the Modulation of Gut Dysbiosis, Inhibition of Renal Inflammation, Oxidative Stress, Fibrosis, and Improve Organic Anion Transporter 3 Function in an Obese Rat Model,Molecular Nutrition & Food Research

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Fructooligosaccharides Ameliorate Renal Injury and Dysfunction Through the Modulation of Gut Dysbiosis, Inhibition of Renal Inflammation, Oxidative Stress, Fibrosis, and Improve Organic Anion Transporter 3 Function in an Obese Rat Model
Molecular Nutrition & Food Research ( IF 4.5 ) Pub Date : 2024-07-17 , DOI: 10.1002/mnfr.202400191
Nattavadee Pengrattanachot ₁ , Laongdao Thongnak ₂ , Sasivimon Promsan ₁ , Nichakorn Phengpol ₁ , Prempree Sutthasupha ₁ , Jiraporn Tocharus _{1,

3,

4} , Anusorn Lungkaphin _{1,

3,

4}

Affiliation

High-fat diet (HFD) consumption causes obesity and gut dysbiosis which induces kidney injury. It has been reported that prebiotics improve gut dysbiosis and insulin sensitivity and decelerate the progression of kidney disease. This study investigates the impact of fructooligosaccharides (FOS) on renoprotection and the prevention of gut dysbiosis and intestinal barrier injury in obese rats.

中文翻译：

低聚果糖通过调节肥胖大鼠模型中的肠道微生态失调、抑制肾脏炎症、氧化应激、纤维化来改善肾损伤和功能障碍，并改善有机阴离子转运蛋白 3 功能

高脂肪饮食（HFD）会导致肥胖和肠道菌群失调，从而导致肾脏损伤。据报道，益生元可以改善肠道菌群失调和胰岛素敏感性，并减缓肾脏疾病的进展。本研究探讨低聚果糖 (FOS) 对肥胖大鼠肾脏保护以及预防肠道菌群失调和肠道屏障损伤的影响。

更新日期：2024-07-17

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