Although it is an effective HIV prevention method, pre-exposure prophylaxis (PrEP) is underutilized in the Southern US. Many people who use drugs (PWUD) have increased susceptibility to HIV which could be lessened by using PrEP. Potential barriers to PrEP use include lack of awareness of PrEP, low knowledge about HIV prevention, low self-efficacy for HIV prevention, inaccurate risk perceptions, and anticipated stigma. The current study examined predisposing, enabling, and reinforcing factors that may predict interest in PrEP. The purpose of the current study was to explore factors associated with interest in and willingness to use daily oral and long acting injectable PrEP among sexually active adult PWUD. The data were collected from adult participants (n = 270) residing in Harris County, TX, who self-reported problematic substance use and who reported oral, anal, or vaginal sex in the six months prior to completing the survey. The survey was distributed and completed online via Qualtrics Panels in March of 2022 and included measures of PrEP and HIV knowledge, PrEP stigma, sexual health self-efficacy, experiences of discrimination, health literacy, and medical mistrust. The majority of participants reported circumstances or behaviors that increased their susceptibility to HIV. Findings indicated that PrEP user stereotypes and PrEP anticipated disapproval by others were associated with interest in using daily oral PrEP and willingness to use long acting injectable PrEP. These results provide insight into reasons for low PrEP uptake among PWUD who live in a high HIV prevalence jurisdiction. Implications for HIV prevention intervention are discussed.

尽管暴露前预防 (PrEP) 是一种有效的艾滋病毒预防方法，但它在美国南部并未得到充分利用。许多吸毒者 (PWUD) 增加了对艾滋病毒的易感性，而使用 PrEP 可以降低这种易感性。 PrEP 使用的潜在障碍包括缺乏对 PrEP 的认识、对 HIV 预防的了解不足、HIV 预防的自我效能感低、风险认知不准确以及预期的耻辱。当前的研究考察了可能预测对 PrEP 兴趣的诱发因素、促成因素和强化因素。本研究的目的是探讨性活跃的成年 PWUD 对使用每日口服和长效注射 PrEP 的兴趣和意愿相关的因素。数据收集自居住在德克萨斯州哈里斯县的成年参与者（ n = 270），他们自我报告了有问题的药物使用情况，并报告了在完成调查前六个月内的口交、肛交或阴道性交。该调查于 2022 年 3 月通过 Qualtrics 小组在线分发和完成，包括 PrEP 和 HIV 知识、PrEP 耻辱感、性健康自我效能、歧视经历、健康素养和医疗不信任的衡量标准。大多数参与者报告了增加他们感染艾滋病毒的易感性的环境或行为。研究结果表明，PrEP 使用者的刻板印象和 PrEP 预期受到其他人的反对与使用每日口服 PrEP 的兴趣和使用长效注射剂 PrEP 的意愿相关。这些结果让我们深入了解生活在艾滋病毒高流行地区的残疾人士中 PrEP 摄入率低的原因。讨论了艾滋病毒预防干预的影响。