OBJECTIVE To evaluate the association between irregular sleep duration and incident diabetes in a U.K. population over 7 years of follow-up. RESEARCH DESIGN AND METHODS Among 84,421 UK Biobank participants (mean age: 62 years) who were free of diabetes at the time of providing accelerometer data in 2013–2015 and prospectively followed until May 2022, sleep duration variability was quantified by the within-person SD of 7-night accelerometer-measured sleep duration. We used Cox proportional hazard models to estimate hazard ratios (HRs) for incident diabetes (identified from medical records, death register, and/or self-reported diagnosis) according to categories of sleep duration SD. RESULTS There were 2,058 incident diabetes cases over 622,080 person-years of follow-up. Compared with sleep duration SD ≤ 30 min, the HR (95% CI) was 1.15 (0.99, 1.33) for 31–45 min, 1.28 (1.10, 1.48) for 46–60 min, 1.54 (1.32, 1.80) for 61–90 min, and 1.59 (1.33, 1.90) for ≥91 min, after adjusting for age, sex, and race. We found a nonlinear relationship (p nonlinearity 0.0002), with individuals with a sleep duration SD of >60 vs. ≤60 min having 34% higher diabetes risk (95% CI 1.22, 1.47). Further adjustment for lifestyle, comorbidities, environmental factors, and adiposity attenuated the association (HR comparing sleep duration SD of >60 vs. ≤60 min: 1.11; 95% CI 1.01, 1.22). The association was stronger among individuals with lower diabetes polygenic risk score (PRS; P interaction ≤ 0.0264) and longer sleep duration (P interaction ≤ 0.0009). CONCLUSIONS Irregular sleep duration was associated with higher diabetes risk, particularly in individuals with a lower diabetes PRS and longer sleep duration.

中文翻译：

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加速计测量的不规则睡眠时间与 2 型糖尿病风险之间的关联：英国生物银行的一项前瞻性队列研究


目的 通过 7 年的随访，评估英国人群睡眠时间不规律与糖尿病发生之间的关联。研究设计和方法 在 2013 年至 2015 年提供加速度计数据时未患有糖尿病的 84,421 名英国生物银行参与者（平均年龄：62 岁）中，并前瞻性随访至 2022 年 5 月，睡眠持续时间变异性通过人内 SD 进行量化7 晚加速计测量的睡眠持续时间。我们使用 Cox 比例风险模型根据睡眠持续时间 SD 的类别来估计糖尿病事件的风险比 (HR)（从医疗记录、死亡登记和/或自我报告的诊断中确定）。结果 在 622,080 人年的随访中，共有 2,058 例糖尿病病例。与睡眠时间 SD ≤ 30 分钟相比，31-45 分钟的 HR (95% CI) 为 1.15 (0.99, 1.33)，46-60 分钟的 HR (95% CI) 为 1.28 (1.10, 1.48)，61-60 分钟的 HR (95% CI) 为 1.54 (1.32, 1.80)。调整年龄、性别和种族后，90 分钟，≥91 分钟为 1.59 (1.33, 1.90)。我们发现了一种非线性关系（p非线性为0.0002），睡眠持续时间SD为>60的个体与≤60分钟相比，糖尿病风险高出34%（95% CI 1.22, 1.47）。对生活方式、合并症、环境因素和肥胖的进一步调整减弱了这种关联（比较 >60 与 ≤60 分钟睡眠持续时间 SD 的 HR：1.11；95% CI 1.01，1.22）。在糖尿病多基因风险评分较低（PRS；P​​ 相互作用 ≤ 0.0264）和睡眠时间较长（P 相互作用 ≤ 0.0009）的个体中，这种相关性更强。结论 不规则的睡眠时间与较高的糖尿病风险相关，特别是对于糖尿病 PRS 较低且睡眠时间较长的个体。