We constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated immunodeficient mouse neonates with human cord blood CD34+ cells, followed by 17β-estradiol hormonal conditioning. THX mice develop a human lymphoid and myeloid immune system, mount mature antibacterial and antiviral neutralizing antibody responses, and are amenable to develop lupus autoimmunity.

中文翻译：

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具有特异性和成熟抗体和自身抗体反应的人源化小鼠


我们通过将人脐带血 CD34+ 细胞移植到未经 γ 照射、基因清髓免疫缺陷的小鼠新生儿中，然后进行 17β-雌二醇激素调节，构建了人源化 (THX) 小鼠。 THX 小鼠发育出人类淋巴和骨髓免疫系统，产生成熟的抗菌和抗病毒中和抗体反应，并且易于发展狼疮自身免疫。