Topical fluid foam has a considerable application value in the field of topical medicine due to benefits such as simple uniform distribution on the skin’s surface, ease of use, and good patient compliance. The longevity of topical fluid foam is crucial in assessing its therapeutic success, particularly in complicated heat and salt settings. Nanoparticles could improve the stability of topical fluid foam, but their density, size, homogeneity, and surface characteristics are difficult to be taken into consideration simultaneously, resulting in the unclear underlying molecular mechanism. In this work, the raspberry-like microspheres (RM) with a high cross-linked structure were synthesized using a simple one-step dispersion polymerization. The stabilizing foam function of RM in fluid foam was connected to their size, surface chemical characteristics, and foaming temperature. The effect of gravity on foam stability induced by liquid flow acceleration of RM competed fiercely with their size and surface chemical characteristics, and this competitive connection was highly influenced by temperature. The unique surface properties of RM1 (polymerization time of 1h) allowed for their irreversible adsorption at the gas-liquid interface following sodium dodecyl sulfate (SDS) adsorption. RM1 could counteract the harmful effect of gravity on foam stability at a high temperature of 60 oC, enhancing the surface elasticity of the liquid film and improving foam stability. This work is a fantastic starting point for the development of novel nanomaterials to improve the stability of topical fluid foam for pharmaceutical and medical applications.

中文翻译：

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微球辅助局部流体泡沫的基本分子机制


外用流体泡沫因其在皮肤表面简单均匀分布、使用方便、患者依从性好等优点，在外用医学领域具有相当大的应用价值。局部液体泡沫的寿命对于评估其治疗成功至关重要，特别是在复杂的热和盐环境下。纳米颗粒可以提高局部流体泡沫的稳定性，但它们的密度、尺寸、均匀性和表面特性很难同时考虑，导致潜在的分子机制尚不清楚。在这项工作中，采用简单的一步分散聚合合成了具有高交联结构的覆盆子状微球（RM）。 RM 在流体泡沫中的稳定泡沫功能与其尺寸、表面化学特性和发泡温度有关。 RM液体流动加速引起的重力对泡沫稳定性的影响与它们的尺寸和表面化学特性激烈竞争，并且这种竞争关系受温度影响很大。 RM1（聚合时间为1小时）独特的表面特性使其在十二烷基硫酸钠（SDS）吸附后能够在气液界面上进行不可逆吸附。 RM1可以抵消60℃高温下重力对泡沫稳定性的有害影响，增强液膜的表面弹性，提高泡沫稳定性。这项工作是开发新型纳米材料的一个极好的起点，以提高制药和医疗应用中局部液体泡沫的稳定性。