Intranasal M2SR (M2-deficient Single Replication influenza virus) vaccine induces robust immune responses in animal models and human subjects. A high-throughput multiplexed platform was used to analyze hemagglutinin-specific mucosal antibody responses in adults after a single dose of H3N2 M2SR. Nasal swab specimens were analyzed for total and hemagglutinin-specific IgA. Significant, dose-dependent increases in mucosal antibody responses to vaccine-matched and drifted H3N2 hemagglutinin were observed in M2SR vaccinated subjects regardless of baseline serum and mucosal immune status. These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.

中文翻译：

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鼻内 M2SR（M2 缺陷型单复制）流感疫苗可诱导成人产生广泛反应性粘膜抗体


鼻内 M2SR（M2 缺陷单复制流感病毒）疫苗可在动物模型和人类受试者中诱导强烈的免疫反应。使用高通量多重平台来分析成人单剂量 H3N2 M2SR 后血凝素特异性粘膜抗体反应。分析鼻拭子样本的总 IgA 和血凝素特异性 IgA。在 M2SR 疫苗接种受试者中，无论基线血清和粘膜免疫状态如何，都观察到粘膜抗体对疫苗匹配和漂移的 H3N2 血凝素的反应显着、剂量依赖性增加。这些数据表明，M2SR 诱导广泛的交叉反应性粘膜免疫反应，这可能会针对漂移和新出现的流感病毒株提供更好的保护。