GC-MS analysis, phytochemical composition of Hertia cheirifolia L. essential oil with pharmacological assessments: antioxidant, antibacterial, and antifungal activities,RSC Advances

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GC-MS analysis, phytochemical composition of Hertia cheirifolia L. essential oil with pharmacological assessments: antioxidant, antibacterial, and antifungal activities
RSC Advances ( IF 3.9 ) Pub Date : 2024-07-17 , DOI: 10.1039/d4ra03578j
Wassila Benabderrahmane ₁ , Hamza Fadel ₂ , Ines Sekhara ₂ , Imad Mennai ₂ , Imed Eddine Kadi ₃ , Mahmoud Helal ₄ , Rokayya Sami ₅ , Hala M Abo-Dief ₆ , Ruqaiah I Bedaiwi ₇ , Mohammad A Alanazi ₇ , Helal F Al-Harthi ₈ , Roqayah H Kadi ₉ , Suzan A Abushal ₁₀ , Tasahil S Albishi ₁₁ , Alaa T Qumsani ₁₂ , Sameer H Qari ₁₂

Affiliation

Department of Chemistry, Faculty of Sciences, University of 20 Août 1955-Skikda PO Box 26 El-Hadaiek Road Algeria
Research Unit Valorization of Natural Resources, Bioactive Molecules, and Physicochemical and Biological Analyses, University of the Mentouri Brothers Constantine1, Aïn El Bey Road 25000 Constantine Algeria
Research Unit in Medicinal Plants (URPM. 3000, Laghouat) Attached to the Research Centre of Biotechnology (CRBt. 25000, Constantine) Algeria
Department of Mechanical Engineering, Faculty of Engineering, Taif University PO 11099 Taif 21944 Saudi Arabia
Department of Food Science and Nutrition, College of Sciences, Taif University PO Box 11099 Taif 21944 Saudi Arabia tu.edu.sa.
Department of Science and Technology, University College-Ranyah, Taif University PO Box 11099 Saudi Arabia
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk PO Box 741 Tabuk 71491 Saudi Arabia
Department of Biology, Turabah University College, Taif University 21995 Saudi Arabia
Department of Biological Sciences, College of Science, University of Jeddah Jeddah 21959 Saudi Arabia
Program of Food Sciences and Nutrition, Turabah University College, Taif University PO 11099 Taif 21944 Saudi Arabia
Biology Department, College of Sciences, Umm Al-Qura University Makkah Saudi Arabia
Department of Biology, Al-Jumum University College, Umm Al-Qura University Makkah Saudi Arabia

The genus Hertia, which belongs to the Asteraceae family, is a flowering genus with 12 species found in Africa, North and South. Among the species present in Algeria, Hertia cheirifolia L. is distributed in the eastern regions of Algeria. The aim of this study is to evaluate its phytochemical composition with following pharmacological assessments: the antioxidant, antibacterial, and antifungal activities of Hertia cheirifolia L. essential oil (EO). GC-MS analysis was used to analyze the chemical constituents of H. cheirifolia essential oil. The antioxidant capacity was assessed using DPPH, FRAP, and H₂O₂ tests. The EO was also tested for its ability to inhibit six strains of microorganisms, including two Gram (+) and four Gram (−) strains. The antifungal activity was tested by analyzing the effect of the EO on the mycelial growth of Fusarium oxysporum f.sp. lycopersici (FOL) fungi. Results showed that primary volatile components were α-pinene (32.59%), 2-(1-cyclopent-1-enyl-1-methylethyl) cyclopentanone (14.62%), (−)-germacrene D (11.37%), and bakkenolide A (9.57%). H. cheirifolia EO showed inhibitory effects against DPPH, H₂O₂, and FRAP (IC₅₀ = 0.34 ± 0.1, 0.053 ± 0.1, and 0.047 ± 0.01 mg mL⁻¹, respectively). The EO also exhibited moderate antibacterial effects against Staphylococcus aureus ATCC 25923 (S. aureus), Streptococcus pneumoniae ATCC 49619 (S. pneumoniae), and Enterobacter aerogenes ATCC 13048 (E. aerogenes), as well as significant antioxidant potential and varied antifungal activity based on dosage and fungal strain. To our knowledge, no previous research has examined the antifungal capacity of H. cheirifolia oil and oil-mycelial development of the FOL relationship. To fully explore the benefits of H. cheirifolia EO, more in vivo research is necessary, along with more testing on other bacterial and fungal strains.

中文翻译：

GC-MS 分析、Hertia cheirifolia L. 精油的植物化学成分以及药理评估：抗氧化、抗菌和抗真菌活性

Hertia属属于菊科，是一个开花属，有 12 个物种，分布于非洲、北部和南部。在阿尔及利亚现有的物种中， Hertia cheirifolia L.分布在阿尔及利亚东部地区。本研究的目的是通过以下药理学评估来评估其植物化学成分： Hertia cheirifolia L.精油（EO）的抗氧化、抗菌和抗真菌活性。采用GC-MS分析方法分析了H. cheirifolia精油的化学成分。使用DPPH、FRAP和H ₂ O ₂测试评估抗氧化能力。还测试了 EO 抑制六种微生物菌株的能力，包括两种革兰氏 (+) 菌株和四种革兰氏 (-) 菌株。通过分析EO对Fusarium oxysporum f.sp菌丝生长的影响来测试其抗真菌活性。番茄(FOL) 真菌。结果表明，主要挥发性成分为α-蒎烯（32.59%）、2-（1-环戊-1-烯基-1-甲基乙基）环戊酮（14.62%）、（−）-香叶烯D（11.37%）和巴克烯内酯A （9.57%）。 H. cheirifolia EO 对 DPPH、H ₂ O ₂和 FRAP 显示出抑制作用（IC ₅₀分别 = 0.34 ± 0.1、0.053 ± 0.1 和 0.047 ± 0.01 mg mL ^-1 ）。 EO 对金黄色葡萄球菌ATCC 25923（金黄色葡萄球菌）、肺炎链球菌ATCC 49619（金黄色葡萄球菌）也表现出中等抗菌作用。肺炎杆菌）和产气肠杆菌ATCC 13048（产气肠杆菌），以及显着的抗氧化潜力和基于剂量和真菌菌株的不同抗真菌活性。据我们所知，之前没有研究检验过H. cheirifolia油的抗真菌能力和 FOL 油-菌丝体发育的关系。为了充分探索H. cheirifolia EO 的益处，需要进行更多的体内研究以及对其他细菌和真菌菌株的更多测试。

更新日期：2024-07-17

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