Gouty arthritis is a chronic and progressive disease characterized by high urate levels in the joints and by an inflammatory immune microenvironment. Clinical data indicate that urate reduction therapy or anti-inflammatory therapy alone often fails to deliver satisfactory outcomes. Here we have developed a smart biomimetic nanosystem featuring a ‘shell’ composed of a fusion membrane derived from M2 macrophages and exosomes, which encapsulates liposomes loaded with a combination of uricase, platinum-in-hyaluronan/polydopamine nanozyme and resveratrol. The nanosystem targets inflamed joints and promotes the accumulation of anti-inflammatory macrophages locally, while the uricase and the nanozyme reduce the levels of urate within the joints. Additionally, site-directed near-infrared irradiation provides localized mild thermotherapy through the action of platinum and polydopamine, initiating heat-induced tissue repair. Combined use of these components synergistically enhances overall outcomes, resulting in faster recovery of the damaged joint tissue.

痛风性关节炎是一种慢性进行性疾病，其特征是关节中高尿酸水平和炎症免疫微环境。临床数据表明，单独的降尿酸治疗或抗炎治疗往往无法带来满意的结果。在这里，我们开发了一种智能仿生纳米系统，其特征是由 M2 巨噬细胞和外泌体衍生的融合膜组成的“外壳”，该系统封装了负载尿酸酶、透明质酸铂/聚多巴胺纳米酶和白藜芦醇组合的脂质体。纳米系统以发炎关节为目标，促进局部抗炎巨噬细胞的积累，而尿酸酶和纳米酶则降低关节内的尿酸盐水平。此外，定点近红外照射通过铂和聚多巴胺的作用提供局部温和热疗，启动热诱导的组织修复。这些成分的联合使用可协同增强整体效果，从而使受损的关节组织更快恢复。