Histoplasmosis is a fungal disease associated with substantial mortality rates among persons with advanced HIV disease. Our systematic review synthesized data on the global prevalence of Histoplasma­-caused antigenuria in persons with HIV. We searched PubMed/Medline, Embase, and Scopus databases on January 3, 2023, to identify cross-sectional and cohort studies evaluating Histoplasma antigenuria prevalence among adults with HIV infection. We calculated point estimates and 95% CIs to summarize prevalence. Of 1,294 studies screened, we included 15. We found Histoplasma antigenuria among 581/5,096 (11%; 95% CI 11%–12%) persons with HIV and 483/3,789 persons with advanced HIV disease (13%; 95% CI 12%–14%). Among persons with HIV and symptoms consistent with histoplasmosis, Histoplasma antigenuria prevalence was 14% (95% CI 13%–15%; 502/3,631 participants). We determined that persons with advanced HIV disease, inpatients, and symptomatic persons might benefit from a systematic approach to early detection of histoplasmosis using urine antigen testing.

组织胞浆菌病是一种真菌病，与晚期艾滋病毒患者的高死亡率相关。我们的系统回顾综合了全球艾滋病毒感染者组织胞浆菌引起的抗原尿流行率的数据。我们于 2023 年 1 月 3 日检索了 PubMed/Medline、Embase 和 Scopus 数据库，以确定评估 HIV 感染成人中组织胞浆菌抗原尿患病率的横断面和队列研究。我们计算了点估计值和 95% CI 来总结患病率。在筛选的 1,294 项研究中，我们纳入了 15 项。我们在 581/5,096 名HIV感染者（11%；95% CI 11%–12%）和 483/3,789 名晚期 HIV 感染者（13%；95% CI 12）中发现组织胞浆菌抗原尿。 %–14%）。在患有符合组织胞浆菌病症状的 HIV 感染者中，组织胞浆菌抗原尿患病率为 14%（95% CI 13%–15%；502/3,631 名参与者）。我们确定，患有晚期艾滋病毒的人、住院患者和有症状的人可能会受益于使用尿抗原检测早期检测组织胞浆菌病的系统方法。