Transient receptor potential melastatin (TRPM) channels have emerged as potential therapeutic targets for cerebral ischemia–reperfusion (I/R) injury. We highlight recent findings on the involvement of TRPM channels in oxidative stress, mitochondrial dysfunction, inflammation, and calcium overload. We also discuss the challenges and future directions in targeting TRPM channels for cerebral I/R injury.

中文翻译：

---

靶向TRPM通道治疗脑缺血再灌注损伤

瞬时受体电位褪黑素（TRPM）通道已成为脑缺血再灌注（I/R）损伤的潜在治疗靶点。我们重点介绍 TRPM 通道参与氧化应激、线粒体功能障碍、炎症和钙超载的最新发现。我们还讨论了针对 TRPM 通道治疗脑缺血再灌注损伤的挑战和未来方向。