Survival of xenograft kidneys in allosensitized recipients is extended when using kidneys from pigs with multiple genetic changes. This observation suggests that highly allosensitized patients could obtain great benefit from clinical implementation of xenotransplantation.

In this preclinical, non-human primate study, rhesus macaques were first highly allosensitized. Next, five of these macaques received a kidney from a GGTA1-knockout pig expressing the human CD55 transgene (1KO.1TG). These macaques received an anti-CD154 monoclonal antibody-based immunosuppressive regimen. Antibody-mediated rejection (AMR) occurred early in these animals, with a mean survival time of 24 days.

当使用来自具有多种遗传变化的猪的肾脏时，同种异体致敏受体的异种移植肾的存活率会延长。这一观察结果表明，高度异体敏感的患者可以从异种移植的临床实施中获得巨大益处。

在这项临床前非人类灵长类动物研究中，恒河猴首先被高度过敏。接下来，其中五只猕猴接受了来自表达人类CD55转基因 (1KO.1TG) 的GGTA1敲除猪的肾脏。这些猕猴接受了基于抗 CD154 单克隆抗体的免疫抑制方案。抗体介导的排斥反应 (AMR) 在这些动物中很早就发生，平均存活时间为 24 天。