Protein desulfurization and deselenization,Chemical Society Reviews

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Protein desulfurization and deselenization
Chemical Society Reviews ( IF 40.4 ) Pub Date : 2024-07-16 , DOI: 10.1039/d4cs00135d
Vincent Diemer ₁ , Eliott Roy ₁ , Vangelis Agouridas _{1,

2} , Oleg Melnyk ₁

Affiliation

Methods enabling the dechalcogenation of thiols or selenols have been investigated and developed for a long time in fields of research as diverse as the study of prebiotic chemistry, the engineering of fuel processing techniques, the study of biomolecule structures and function or the chemical synthesis of biomolecules. The dechalcogenation of thiol or selenol amino acids is nowadays a particularly flourishing area of research for being a pillar of modern chemical protein synthesis, when used in combination with thiol or selenol-based chemoselective peptide ligation chemistries. This review offers a comprehensive and scholarly overview of the field, emphasizing emerging trends and providing a detailed and critical mechanistic discussion of the dechalcogenation methods developed so far. Taking advantage of recently published reports, it also clarifies some unexpected desulfurization reactions that were observed in the past and for which no explanation was provided at the time. Additionally, the review includes a discussion on principal desulfurization methods within the framework of newly introduced green chemistry metrics and toolkits, providing a well-rounded exploration of the subject.

中文翻译：

蛋白质脱硫脱硒

长期以来，在生命起源化学研究、燃料加工技术工程、生物分子结构和功能研究或生物分子化学合成等多种研究领域中，已经对硫醇或硒醇脱硫属化的方法进行了研究和开发。。当与基于硫醇或硒醇的化学选择性肽连接化学结合使用时，硫醇或硒醇氨基酸的脱硫属化是当今特别蓬勃的研究领域，因为它是现代化学蛋白质合成的支柱。这篇综述对该领域进行了全面的学术概述，强调了新兴趋势，并对迄今为止开发的脱硫方法进行了详细而关键的机制讨论。利用最近发表的报告，它还澄清了一些过去观察到的、当时未提供解释的意外脱硫反应。此外，审查还包括在新引入的绿色化学指标和工具包框架内对主要脱硫方法的讨论，为该主题提供了全面的探索。

更新日期：2024-07-16

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