2‐Azabicyclo[2.2.1]hept‐5‐en‐3‐one (Vince lactam) is known to be a valuable building block in synthetic organic chemistry and drug research. It is an important precursor to access of some blockbuster antiviral drugs such as Carbovir or Abacavir as well as other carbocyclic neuraminidase inhibitors as antiviral agents. The ring C=C bond of the Vince lactam allows versatile chemical manipulations to create not only functionalized γ‐lactams, but also γ‐amino acid derivatives with a cyclopentane framework. The aim of the current account is to summarize the chemistry of Vince lactam, its synthetic utility and application in organic and medicinal chemistry over the last decade.

中文翻译：

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2-氮杂双环[2.2.1]Hept-5-En-3-One（Vince Lactam）在有机合成和药物化学中的应用


2-氮杂双环[2.2.1]hept-5-en-3-one（Vince内酰胺）被认为是有机合成化学和药物研究中有价值的组成部分。它是获得一些重磅抗病毒药物（例如卡波韦或阿巴卡韦）以及其他碳环神经氨酸酶抑制剂作为抗病毒药物的重要前体。 Vince 内酰胺的环 C=C 键允许多种化学操作，不仅可以产生功能化的 γ-内酰胺，还可以产生具有环戊烷骨架的 γ-氨基酸衍生物。本报告的目的是总结过去十年 Vince 内酰胺的化学性质、合成效用以及在有机化学和药物化学中的应用。