The increased availability of myositis autoantibodies represents new possibilities and challenges in clinical practice (Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76:1955–64. https://doi.org/10.1136/annrheumdis-2017-211468 .). The aim of this study was to perform a retrospective data analysis of patient cases with positive myositis autoantibodies to analyse their significance in routine rheumatology practice. A monocentric analysis of all the orders used to determine myositis autoantibodies from July 2019 to May 2022 in the Department of Rheumatology, Krankenhaus Porz am Rhein, Cologne, Germany, was carried out. In the defined time interval, a total of 71,597 laboratory values for the antibodies mentioned above were obtained. A total of 238 different positive autoantibodies ​​were detected in 209 patients. Idiopathic inflammatory myopathy was diagnosed in 37 patients (18%), and inflammatory rheumatic diseases other than idiopathic inflammatory myopathy were diagnosed in 90 patients (43%). No inflammatory rheumatic disease was diagnosed in 82 patients (39%). General clusters of clinical manifestations were observed. In our cohort, we were able to show that a relevant proportion of patients with positive myositis antibodies did not have idiopathic inflammatory myopathies or inflammatory rheumatic diseases. This finding indicates the importance of myositis autoantibodies in this group of patients. However, further studies on the course of symptoms and examination results in patients without inflammatory rheumatic diseases and with positive myositis antibodies are necessary.

中文翻译：

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风湿病中肌炎抗体阳性的临床相关性：回顾性单中心分析


肌炎自身抗体可用性的增加代表了临床实践中新的可能性和挑战（Lundberg IE、Tjärnlund A、Bottai M、Werth VP、Pilkington C、de Visser M 等人。2017 年欧洲抗风湿病联盟/美国风湿病学会分类标准成人和青少年特发性炎症性肌病及其主要亚组。Ann Rheum Dis.2017；76：1955–64 https://doi.org/10.1136/annrheumdis-2017-211468。本研究的目的是对肌炎自身抗体阳性的患者病例进行回顾性数据分析，以分析其在常规风湿病实践中的意义。对德国科隆 Krankenhaus Porz am Rhein 风湿病科 2019 年 7 月至 2022 年 5 月用于测定肌炎自身抗体的所有订单进行了单中心分析。在规定的时间间隔内，总共获得了 71,597 个上述抗体的实验室值。 209名患者中总共检测到238种不同的阳性自身抗体。 37 名患者（18%）诊断出特发性炎症性肌病，90 名患者（43%）诊断出特发性炎症性肌病以外的炎症性风湿性疾病。 82 名患者 (39%) 未诊断出炎症性风湿病。观察到一般的临床表现。在我们的队列中，我们能够证明肌炎抗体阳性的患者中有相当比例没有特发性炎症性肌病或炎症性风湿病。这一发现表明肌炎自身抗体在这组患者中的重要性。 然而，对于无炎症性风湿性疾病且肌炎抗体阳性的患者的症状过程和检查结果，还需要进一步研究。