In this study, we report an experimental protocol based on gold nano particles (GNPs) for the selective and efficient chromogenic detection and determination of glutathione from its two pharmaceutical samples viz. Maxiliv and Glutaderm in real time. The glucosamine hydrochloride driven hydrothermal (400C) wet chemical reduction of gold (III)chloride trihydrate resulted into gold sol with ruby red color exhibiting its surface plasmon resonance (SPR) at 521nm. The most frequent average size of these GNPs was found to be 23 nm while their concentration was evaluated to be 8.4 nM. The zeta potential measurements and interaction of these GNPs against NaCl of varying molarities indicated their long-term stability. These GNPs exhibited the morphology of nanowire in their SEM picture and produced a categorical color change from ruby red to blue selectively with GSH from a wide range of similar type of analytes in real time. The UV-Vis, FT-IR, XPS, SEM, TEM, AFM, EDAX, DLS, Zeta potential etc. were used to characterize the as synthesized GNPs as well as to study their interaction pattern with glutathione.

中文翻译：

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氨基葡萄糖功能化金纳米粒子，用于实际样品中谷胱甘肽的特异性检测和比色测定


在这项研究中，我们报告了一种基于金纳米颗粒 (GNP) 的实验方案，用于选择性、高效地显色检测和测定两种药物样品中的谷胱甘肽。 Maxiliv 和 Glutaderm 实时。盐酸葡萄糖胺驱动的水热（400°C）湿法化学还原三水氯化金（III）产生红宝石色的金溶胶，在 521nm 处表现出表面等离振子共振（SPR）。这些 GNP 最常见的平均大小为 23 nm，而其浓度评估为 8.4 nM。 Zeta 电位测量以及这些 GNP 与不同摩尔浓度 NaCl 的相互作用表明了它们的长期稳定性。这些 GNP 在 SEM 图片中展示了纳米线的形态，并利用来自各种类似类型分析物的 GSH 选择性地实时产生从宝石红到蓝色的分类颜色变化。 UV-Vis、FT-IR、XPS、SEM、TEM、AFM、EDAX、DLS、Zeta 电位等用于表征合成的 GNP 并研究其与谷胱甘肽的相互作用模式。